CRISPR/Cas9-mediated genome engineering of the ferret  

作　　者：Zhaohui Kou Qian Wu Xiaochen Kou Chonghai Yin Hong Wang Zhentao Zuo Yan Zhuo Antony Chen Shaorong Gao Xiaoqun Wang 

机构地区：[1]State Key Laboratory of Brain and Cognitive Science,CAS Center for Excellence in Brain Science and Intelligence Technology(Shanghai),Beijing MRI Centre for Brain Research,Institute of Biophysics,Chinese Academy of Sciences,Beijing Institute for Brain Disorders,Beijing 100101,China [2]Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China [3]Wuxi Sangosho Biotechnology Corporations,Wuxi,Zhejiang 214142,China

出　　处：《Cell Research》2015年第12期1372-1375,共4页细胞研究（英文版）

摘　　要：Dear Editor, Ferrets （Mustela putorius furo） have served as one of the most valuable animal models for recapitulating hu- man disease since 1933 [1]. This is because they show many similarities to humans in terms of physiological features of brain function and reproductive biology as well as pathological characteristics of various diseases such as cancer, influenza infection and cystic fibrosis [2- 4]. Despite these advantages, the current use of ferrets in research is significantly limited due to the lack of a meth- od enabling precise genetic modification.

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分 类 号：U469.11[机械工程—车辆工程] X53[交通运输工程—载运工具运用工程]