超分子类肽纳米片层的全自动高通量制备  

Full-automatic and High-throughput Formation of Supramolecular Peptoid Nanosheet

作　　者：覃茂昌 郑晖[3] 胡志远[2,4] 李勤[1] 

机构地区：[1]北京理工大学生命学院,北京100081 [2]国家纳米科学中心纳米生物效应与安全性研究室,北京100190 [3]中国科学院化学研究所活体分析化学实验室,北京100190 [4]长三角(嘉兴)纳米科技产业发展研究院,浙江嘉兴314000

出　　处：《生命科学仪器》2015年第6期54-58,50,共6页Life Science Instruments

基　　金：国家重大科学仪器设备开发专项课题(2012YQ04014005)

摘　　要：类肽是以N-取代甘氨酸为合成单元的类似多肽的非天然化合物。类肽保留了多肽可折叠可自组装的优点,同时类肽组成单元的多样性导致其结构多样性,使得类肽获得比多肽更多样的化学、生物活性。目前,其良好的生物活性和药理性质使得人们开始关注其在化学、生物和药学等领域应用。我们开发一种非朗缪尔槽的方法,利用少量样品就可以高效进行全自动和高通量的两维类肽纳米片层的制备,该方法可快速优化类肽自组装的条件,并可以用在其它肽类超分子的自组装研究。Peptoid, the N-substituted glycines, is a kind of artifi cial peptide analogue. Different from peptide, the side-chain is on the nitrogen rather than α-carbon. As a result, peptoid has more diverse chemical and biological activities. It not only keeps the advantages of the peptide＇s self-assemble and folding, but also has diversity structure due to its plentiful kinds of component unit. it＇s the good biological activity and pharmacological properties of peptoid make people begin to pay close attention to its application in the fi eld of chemistry, biology and pharmacy, etc. We developed a kind of method, which can use a small amount of sample, but be effi cient for automatic and high fl ux preparation of two dimensional peptoid nanometer lamella. Besides, this method can quickly optimize peptoid nanosheet self-assembly conditions, and can be used other peptide supramolecular selfassembly research.

关 键 词：类肽分子 两维纳米材料 超低速纳米片层合成仪 高通量 

分 类 号：O641.3[理学—物理化学]