异种骨治疗骨缺损的瓶颈及发展趋势  

Bottleneck and development trend of bone xenograft for the treatment of bone defect

作　　者：李保亮[1] 刘雷[1] 赵文博[1] 栾富均[2] 李沁[3] 

机构地区：[1]四川大学华西医院骨科,四川成都610041 [2]重庆医科大学附属永川医院,重庆402160 [3]四川大学华西医院承办西藏分院,四川成都610041

出　　处：《中国骨伤》2015年第12期1166-1170,共5页China Journal of Orthopaedics and Traumatology

摘　　要：异种骨具有来源广泛、价格低廉、制备方法较为简单等优势,利用其修复骨缺损当前研究热点。单纯异种骨材料修复骨缺损的临床过程较长,效果差强人意,主要困扰为置入体内后的成骨和血管化。将细胞及细胞因子与异种骨材料组成重组异种骨,并通过多种方式促进其血管化可加速其与体内骨融合,具有达到自体骨修复骨缺损临床效果的发展前景。Bone xenograft bone for the treatment of bone defect is one of the current research focus,which has advantages of extensive sources,low cost,simple preparation method. While the process of single bone xenograft bone in repairing bone defect is very long,and the clinical outcome is not satisfactory. The main problems focus on formation of bone and vascularization. Reconstituted bone xenograft combined with cells and xenogenic bone material could promote vascularization and bone fusion in vivo,thus achieve a clinical effect of autogenous bone in repairing bone defect.

关 键 词：修复外科手术 新生血管化 病理性 综述文献 

分 类 号：R318.17[医药卫生—生物医学工程]