Uncovering the underlying physical mechanisms of biological systems via quantification of landscape and flux  

作　　者：徐丽 楚夏昆 晏致强 郑喜亮 张坤 张锋 闫晗 吴畏 汪劲 

机构地区：[1]State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]Department of Chemistry and Physics,Stony Brook University,Stony Brook,NY 11794-3400,USA

出　　处：《Chinese Physics B》2016年第1期244-269,共26页中国物理B（英文版）

基　　金：supported by the Natural Science Foundation of China(Grant Nos.21190040,11174105,91225114,91430217,and 11305176);Jilin Province Youth Foundation,China(Grant No.20150520082JH)

摘　　要：In this review, we explore the physical mechanisms of biological processes such as protein folding and recognition, ligand binding, and systems biology, including cell cycle, stem cell, cancer, evolution, ecology, and neural networks. Our approach is based on the landscape and flux theory for nonequilibrium dynamical systems. This theory provides a unifying principle and foundation for investigating the underlying mechanisms and physical quantification of biological systems.In this review, we explore the physical mechanisms of biological processes such as protein folding and recognition, ligand binding, and systems biology, including cell cycle, stem cell, cancer, evolution, ecology, and neural networks. Our approach is based on the landscape and flux theory for nonequilibrium dynamical systems. This theory provides a unifying principle and foundation for investigating the underlying mechanisms and physical quantification of biological systems.

关 键 词：LANDSCAPE FLUX 

分 类 号：Q61[生物学—生物物理学]