Flexibility of nucleic acids: From DNA to RNA  

作　　者：鲍磊 张曦 金雷 谭志杰 

机构地区：[1]Department of Physics and Key Laboratory of Artificial Micro-and Nano-structures of Ministry of Education,School of Physics and Technology, Wuhan University

出　　处：《Chinese Physics B》2016年第1期313-323,共11页中国物理B（英文版）

基　　金：supported by the National Basic Research Program of China(Grant No.2011CB933600);the National Natural Science Foundation of China(Grant Nos.11175132,11575128,and 11374234);the Program for New Century Excellent Talents,China(Grant No.NCET 08-0408)

摘　　要：The structural flexibility of nucleic acids plays a key role in many fundamental life processes, such as gene replication and expression, DNA-protein recognition, and gene regulation. To obtain a thorough understanding of nucleic acid flexibil- ity, extensive studies have been performed using various experimental methods and theoretical models. In this review, we will introduce the progress that has been made in understanding the flexibility of nucleic acids including DNAs and RNAs, and will emphasize the experimental findings and the effects of salt, temperature, and sequence. Finally, we will discuss the maior unanswered questions in understanding the flexibility of nucleic acids.The structural flexibility of nucleic acids plays a key role in many fundamental life processes, such as gene replication and expression, DNA-protein recognition, and gene regulation. To obtain a thorough understanding of nucleic acid flexibil- ity, extensive studies have been performed using various experimental methods and theoretical models. In this review, we will introduce the progress that has been made in understanding the flexibility of nucleic acids including DNAs and RNAs, and will emphasize the experimental findings and the effects of salt, temperature, and sequence. Finally, we will discuss the maior unanswered questions in understanding the flexibility of nucleic acids.

关 键 词：DNA RNA FLEXIBILITY computer simulation 

分 类 号：Q52[生物学—生物化学]