MMP-2、MMP-9和VEGF在子宫内膜异位症中的表达及其意义  

The expression and significances of MMP-2,MMP-9 and VEGF in patients with endometriosis

作　　者：喻长法[1] 叶丽君[1] 段达荣[1] 王政[1] 许丽娜[1] 

机构地区：[1]浙江省台州市第一人民医院,浙江台州318020

出　　处：《中国优生与遗传杂志》2016年第1期34-35,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨基质金属蛋白酶-2、-9（MMP-2、MMP-9）及血管内皮生长因子（VEGF）在子宫内膜异位症（EMs）患者血清及腹腔液中的表达及其意义。方法收集2012年1月～2014年12月来本院就诊的96例EMs和30例对照组患者血清和腹腔液，用酶联免疫吸附法（ELISA）检测MMP-2、MMP-9和VEGF浓度，并将各组结果进行对比分析。结果EMs组患者血清和腹腔液中MMP-2、MMP-9和VEGF的浓度显著高于对照组水平（P〈0．05），MMP-2、MMP-9和VEGF在EMs组患者Ⅲ-Ⅳ期血清和腹腔液中浓度显著高于Ⅰ—Ⅱ期，VEGF在Ⅰ-Ⅱ期血清和腹腔液中浓度显著高于对照组（P〈0．05）。结论MMP-2、MMP-9和VEGF在EMs患者的血清及腹腔液中高表达，提示其与EMs发生发展存在密切相关。Objective： To study the expression and significance of matrix metalloproteinase-2, -9 （MMP-2, MMP-9） and vascular endothelial growth factor （VEGF） in serum and peritoneal fluid in patients with endometriosis （EMs） . Methods： The sample of serum and peritoneal fluid was collected from 96 cases patients with EMs and 30 cases control group from Jan. 2012 to Dec. 2014.The method of Enzyme-linked immunosorbent assay （ELISA） was used to test the concentration of MMP-2, MMP-9 and VEGF, and the group results were analyzed. Results： The concentration of MMP-2, MMP-9 and VEGF in serum and peritoneal fluid in patients with EMs group was significantly higher than that of the control group （P〈0.05） . The concentration of MMP-2, MMP-9 and VEGF in serum and peritoneal fluid in EMs group in Ⅲ-Ⅳstage was significantly higher than that of Ⅰ-Ⅱ stage, and the concentration of VEGF in serum and peritoneal fluid in Ⅰ-Ⅱ stage was significantly higher than that of the control group （P〈0.05） . Conclusion： The high expression of MMP-2, MMP-9 and VEGF in serum and peritoneal fluid in patients with EMs, it is closely related to the occurrence and development of EMs.

关 键 词：子宫内膜异位症 基质金属蛋白酶-2 -9 血管内皮生长因子 

分 类 号：R711.71[医药卫生—妇产科学]