柴葛解肌处方抗炎活性部位筛选  

Screening of Anti-inflammatory Fraction of Chaige Jieji Prescription

作　　者：曾俊芬[1] 鲁建武[1] 宋金春[1] 徐明霞[1] 

机构地区：[1]武汉大学人民医院药学部,武汉430060

出　　处：《中国药师》2016年第1期67-69,共3页China Pharmacist

摘　　要：目的:筛选柴葛解肌处方的抗炎活性部位。方法:采用昆明种小鼠,以二甲苯致小鼠耳廓肿胀实验和角叉菜胶致小鼠足趾肿胀实验考察柴葛解肌处方不同部位的抗炎作用以及对PGE_2含量的影响。结果:柴葛解肌处方乙酸乙酯和正丁醇部位对小鼠耳廓肿胀以及小鼠足趾肿胀有显著抑制作用,正丁醇部位在0.8·kg^(-1)时对小鼠肿胀耳廓抑制率为51.9%,对小鼠足趾肿胀抑制率为37.45%(P<0.01),且其PGE_2含量显著减少(P<0.01)。结论:柴葛解肌处方正丁醇部位为其主要抗炎部位,能抑制小鼠耳廓和足趾肿胀,减少PGE_2含量。Objective： To screen the anti-inflammatory fraction of Chaige Jieji prescription. Methods： The auricle edema model was induced by dimethylbenzene and the paw edema model was induced by carrageenan in Kunming mice to study the anti-inflammatory effects of different fractions, and the content of proateglandin E2 （ PGE2 ） was measured determined. Results： Acetic ether part and n- butyl alcohol part of Chaige Jieji prescription could relieve the auricle edema and paw edema. The inhibition rate of n-butyl alcohol part at the dose of 0.8 g · kg-1 for the auricle edema and paw edema was 5l. 9% and 37.45% , respectively（P 〈0.01 ）, and the content of PGE2 was decreased significantly（ P 〈 0.01 ）. Conelusion： n-Butyl alcohol part of Chaige Jieji prescription is the main active fraction, which can relieve auricle edema and paw edema, and decrease the content of PGE2.

关 键 词：柴葛解肌处方 抗炎 活性部位 

分 类 号：R285.5[医药卫生—中药学]