七氟烷与氯胺酮麻醉诱导用于患儿全身麻醉效果观察  

Efficacy of Sevoflurane and Ketamine in Anesthesia Induction for Children General Anesthesia

作　　者：於立伟 朱小勇[1] 陆文英[1] 宋少波[1] 余静[1] 

机构地区：[1]浙江萧山医院麻醉科,杭州311200

出　　处：《中国药师》2016年第1期142-144,共3页China Pharmacist

摘　　要：目的:观察比较七氟烷与氯胺酮麻醉诱导用于患儿全身麻醉的效果。方法:90例手术患儿随机分为两组。七氟烷组采用七氟烷面罩吸入麻醉诱导,氯胺酮组患儿予氯胺酮静注麻醉诱导。监测记录两组患儿麻醉过程中的平均动脉压(MAP)、心率(HR)、血氧饱和度(S_pO_2),以及麻醉诱导时间、苏醒时间、定向力恢复时间、出手术室时间以及并发症发生情况。结果:麻醉后与切皮时,两组患儿的MAP、HR均较入室时均明显升高(P<0.05),而氯胺酮组切皮时的MAP、HR明显高于七氟烷组(P<0.05)。七氟烷组患儿的诱导时间、苏醒时间、手术时间、定向力恢复时间及出手术室时间均明显短于氯胺酮组(P<0.01);术后并发症的发生率明显低于氯胺酮组(P<0.01)。结论:七氟烷麻醉诱导在患儿全身麻醉中应用效果良好,安全性高,值得临床推广应用。Objective： To observe the application effect of sevoflurane and ketamine in anesthesia induction for children general anesthesia. Methods： Totally 90 children were randomly divided into two groups. Sevoflurane group was anesthetized with sevoflurane inhalation, and ketamine group was anesthetized with ketamine by intravenous injection. The mean arterial pressure （MAP）, heart rate （HR）, blood oxygen saturation （SpO2 ） , time of anesthesia induction, recovery time of consciousness, recovery time of directional power and complications in the two groups during anesthesia were monitored and recorded. Results： After anesthesia, the MAP and HR were significantly increased in the two groups when skin incision was performed （P 〈 0.05 ） , and the increase in ketamine group was higher than that in sevoflurane group （ P 〈 0.05 ）. The induction time, recovery time of consciousness, operation duration, recovery time of directional power and the time coming out the operating room in sevoflurane group were shorter than those in ketamine group （P 〈0.01 ）. The incidence of postoperative complications in sevofinrane group was significantly lower than that in ketamine group （P 〈 0.01 ）. Conclusion： The effect of sevoflurane anesthesia induction in children with general anesthesia is good with high safety, which is worthy of clinical application.

关 键 词：全身麻醉 七氟烷 氯胺酮 患儿 

分 类 号：R971.2[医药卫生—药品]