控释片剂激光打孔机的研制  

Study of a Laser Machine to Make Hole in Control Tablet

作　　者：赵炎生[1] 王长芳[1] 夏毅 屠锡德[1] 

机构地区：[1]中国药科大学,地质矿产部南京综合岩矿测试中心

出　　处：《东南大学学报（自然科学版）》1998年第6期50-53,共4页Journal of Southeast University：Natural Science Edition

摘　　要：报道一种利用激光束在控释片剂上产生预定释药小孔的激光打孔机．仪器步进式工作，由伺服传动系统联动控制激光脉冲通断与片剂的传送．从而使片剂的储料、输送、定位、打孔、出料程序自动化进行．打孔速率１～２片／ｓ，孔径范围０１～１０ｍｍ．经过对盐酸普鲁卡因胺渗透泵片与盐酸维拉帕米渗透泵片的打孔应用。This paper reports the study of laser holing machine using laser beam to make an orifice for designed diameter on a control tablet.This machine works steppedly,the on or off of laser pulse and the transmission of tablets are controlled by a servo machine linking system.So the storing,transmission,locating,holing and outputing of tablets can be operated automatically. The speed is 1-2 pcs per second, the diameter of orifice can be controlled in the range of 0.1-1.0mm.In the application of drilling holes in the procainamide hydrochloride and verapamil hydrochloride osmotic pump tablet,it is proved that the machine can satisfy the requirement of studying and producing control tablet in a small batch.

关 键 词：激光打孔 渗透泵控释片 研制 工作原理 控释片剂 激光打孔机 

分 类 号：TQ460.5[化学工程—制药化工]