硫酸氯喹的精制工艺改进  

Improvement on Refining Process of Chloroquilonine Sulfate Monohydrate

作　　者：罗彦凤[1] 古昌红[2] 陈建忠 

机构地区：[1]重庆大学生物工程学院,重庆400044 [2]渝州大学化学系,重庆400033 [3]重庆西南制药二厂,重庆400045

出　　处：《重庆大学学报（自然科学版）》2002年第2期49-51,共3页Journal of Chongqing University

摘　　要：研究了乙醇、异丙醇和丙酮等溶剂对硫酸氯喹成品性能 (色泽、澄清度、熔点、晶形 )和收率的影响 ,发现单独以乙醇或异丙醇为重结晶溶剂时 ,所得成品的晶形和澄清度良好 ,收率也高 ,但色泽泛绿 ,熔点不稳定 ;单独以丙酮为重结晶溶剂时 ,所得成品的色泽良好、熔点稳定 ,但晶形和澄清度差 ,收率低。为克服单一溶剂的缺点 ,采用乙醇 -丙酮混合溶剂重结晶硫酸氯喹 ,发现用V(乙醇 ) :V(丙酮 ) =1:4的混合溶剂重结晶硫酸氯喹 ,所得成品色泽、澄清度和晶形良好 ,熔点稳定 ,符合BP93要求 。Effects of solvents such as ethanol, isopropanol and acetone on the qualities of chloroquinoline sulfate such as color, clarity, melting point and crystalline form are studied in detail. The results indicat that a single solvent of ethanol or isopropanol makes end_product greenish with an indefinite melting point but an excellent clarity and a relatively high yield; a single solvent of acetone, however, greatly improved the color and the stability of melting point, but decreased the yield and the clarity. Based on the results above, the mixture of these solvents are required to get the optimum of this product. An optimum solvent composed of V (ethanol(95%)): V (acetone)=1:4 are determined and used to prepare chloroquinoline sulfate, whose qualities are up to BP93.

关 键 词：精制工艺改进 硫酸氯喹 溶剂 重结晶 抗疟药 收率 成品性能 

分 类 号：TQ463.54[化学工程—制药化工] TQ460.64