体外震波与心肌血管新生:对内源性干细胞、细胞因子、局部微环境的影响  

Extracorporeal shock wave and myocardial angiogenesis: effects on endogenous stem cells, cytokines and local microenvironment

作　　者：马一铭 李丽[1] 蔡红雁[1] 郭涛[1] 

机构地区：[1]昆明医科大学第一附属医院心内科,云南省昆明市650000

出　　处：《中国组织工程研究》2015年第45期7374-7380,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81260027);项目名称为"体外心脏震波治疗促进心肌动脉生成机制研究";云南省科技计划项目(2014FZ023);项目名称为"低能量超声震波诱导心肌微环境改变对内皮祖细胞的影响及心肌血管新生的研究";云南省卫生厅科技计划项目(2012WS0005);项目名称为"超声震波对人脐静脉内皮细胞相关细胞因子表达及信号传导通路影响的研究"~~

摘　　要：背景:研究证明体外震波治疗是一种有效、安全和无创的治疗缺血性心脏病的方法,它能促进缺血心肌血管新生。目的:总结体外震波促进缺血心肌血管新生作用的研究进展。方法:运用计算机检索Pubmed和中国知网1998至2014年相关文献,英文检索词为"shock wave,ischemic heart disease,angiogenesis,cytokine,stem cell",中文检索词为"震波、缺血心肌、血管新生、细胞因子、干细胞"。纳入关于体外震波促进缺血性心血管病血管新生的相关文献,排除重复性研究,选取51篇文献进行综述。结果与结论:体外震波动员干细胞增殖、分化为血管内皮细胞,提高血管生长因子(如血管内皮生长因子和碱性成纤维细胞生长因子)高表达,并通过抑制炎症、氧化应激和凋亡以及调控血管外基质为血管新生创造一个有利的微环境,从而间接促进缺血心肌血管新生。体外震波治疗在缺血心肌血管新生中起重要作用,其治疗缺血性心脏病可能有很好的临床运用前景,但具体机制有待进一步研究。BACKGROUND： Studies have shown that extracorporeal shock wave therapy is an effective, safe, and non-invasive treatment for ischemic heart disease, which can improve angiogenesis in the ischemic myocardium. OBJECTIVE： To summarize the research advances in promotion of angiogenesis for ischemic myocardium by extracorporeal shock wave therapy.METHODS： A computer-based online search of Pub Med database and CNKI database was performed for relevant articles published between 1998 and 2014 with key words of ＂shock wave, ischemic heart disease, angiogenesis, cytokine, stem cell＂ in English and Chinese, respectively. Articles related to the promotion ofangiogenesis for ischemic cardiovascular disease by extracorporeal shock wave were selected. Repetitive articles were excluded. According to inclusion criteria, 51 literatures were selected in result analysis. RESULTS AND CONCLUSION： Extracorporeal shock wave therapy can improve angiogenesis in the ischemic myocardium by mobilizing proliferation and differentiation of stem cells into vascular endothelial cells, and by enhancing the expression of growth factors such as vascular endothelial growth factor and basic fibroblast growth factor. Moreover, the extracorporeal shock wave therapy can create a local favorable microenvironment for angiogenesis by inhibiting inflammation, oxidative stress and apoptosis and by regulating components of the extracellular matrix. Extracorporeal shock wave therapy plays an important role in the angiogenesis of ischemic myocardium and displays a good clinical prospect in the treatment of ischemic heart disease. However, the specific mechanism requires further studies.

关 键 词：心肌缺血 新生血管化 生理性 细胞因子类 组织工程 干细胞 移植 体外震波治疗 缺血心肌 血管新生 细胞因子 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]