周细胞概念及在血管形成信号转导通路研究中的进展  

Pericyte-related signaling pathways in angiogenesis

作　　者：蒋福林[1] 艾冬青[2] 官秋玥[3] 

机构地区：[1]口腔疾病研究国家重点实验室(四川大学)四川大学华西口腔医院正畸科,四川省成都市610041 [2]口腔疾病与生物医学重庆市重点实验室重庆医科大学附属口腔医院正畸科,重庆市401147 [3]四川省人民医院草堂病区老年病房,四川省成都市610071

出　　处：《中国组织工程研究》2015年第46期7504-7508,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81371172);四川省科技厅应用基础项目(2013JY0031)~~

摘　　要：背景:周细胞广泛分布于除淋巴管外的所有微脉管中,它不仅是微血管的构成成分,还在微血管的发生、发展、稳定、成熟以及再塑形过程中起着重要作用,其信号转导是目前研究的热点。目的:对近年来周细胞与血管生成相关的信号通路研究进展作以综述。方法:以"pricytes;endothelial cells;microvessels;signal transduction"为英文关键词;以"周细胞;内皮细胞;微血管;信号转导"为中文关键词,计算机检索PubM ed、万方、知网、中国生物医学文献数据库(CBM),1994至2014年与周细胞、血管生成研究相关的文献,就周细胞及其与内皮细胞相互作用的相关信号通路作一阐述。结果与结论:毛细血管形成早期,周细胞的募集可促使新生毛细血管的发生和发展;血管形成后期,周细胞则抑制内皮细胞增生,促进内皮细胞分化,从而促进血管成熟,维持正常节构和调节其通透性。血小板衍生生长因子B/血小板衍生生长因子受体β、转化生长因子β、血管生成素1/Tie-2、人肝素结合性表皮生长因子/Erb Bs、基质细胞衍生因子1α/CXCR4等信号通路对周细胞及血管生成发挥着重要的调节作用。BACKGROUND：Pericytes, which are widely distributed in the microvasculature except lymphatic vessels, are not only a constituent of microvessels, but also play an important role in microvascular occurrence, development, stability, maturity and remodeling. Its signal transduction is currently a hot spot. OBJECTIVE：To review recent advances in the signal pathways related to pericytes and angiogenesis. METHODS：We retrieved PubMed database, Wanfang database, CNKI database and China Biology Medicine disc for articles addressing pericytes and angiogenesis published from 1994 to 2014. The keywords were “pricytes; endothelial cels; microvessels; signal transduction” in English and Chinese, respectively.RESULTS AND CONCLUSION：In the early stage of capilary formation, recruitment of pericytes contributes to the occurrence and development of new blood capilaries. However, in the late stage of angiogenesis, pericytes inhibit endothelial cel proliferation and promote endothelial cel differentiation, thereby promoting vascular maturation, maintaining normal structure and regulating their permeability. In this process, signaling pathways of platelet-derived growth factor B/platelet-derived growth factor receptor β, transforming growth factor β, angiopoietin-1/Tie-2, human heparin binding epidermal growth factor/ErbBs, and stromal cel derived factor 1α/CXCR4 play an important regulatory role in pericytes and angiogenesis.

关 键 词：组织构建 组织工程 周细胞 内皮细胞 血小板衍生生长因子 微血管 信号转导 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]