Sonic Hedgehog信号通路在胚胎发育及神经修复中的现状与进展  

Role of Sonic Hedgehog signal pathway in embryogenesis and neural regeneration

作　　者：王苏平[1] 吴晓君[2] 闫旭[2] 赵红[1] 

机构地区：[1]大连市中心医院神经内一科,辽宁省大连市116033 [2]大连医科大学,辽宁省大连市116044

出　　处：《中国组织工程研究》2015年第46期7523-7528,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:多项研究表明Sonic Hedgehog(Shh)信号通路可调控神经细胞的增殖、分化和轴突形成,参与脑损伤后的神经再生。目的:总结Shh信号通路在胚胎发育及出生后神经修复中的作用。方法:由第一作者检索Pub Med数据库及CNKI全文数据库1980年1月至2015年7月的相关文献,并进行筛选,归纳和总结。英文检索词为"Shh signal pathway,embryogenesis,neural regeneration",中文检索词为"Shh信号通路,胚胎发育,神经修复",选择有关Shh在胚胎期细胞分化、组织发育中的研究及出生后参与神经修复,轴突迁移导向及肿瘤发生发展的相关研究,共检索38篇。结果与结论:近年来Shh信号通路因与脑损伤后神经组织修复的密切关系而备受关注。Shh在Hedgehog(Hh)家族中具有最广泛表达,在胚胎发育、器官形成中起着重要的作用,参与神经系统模式发生、调控前体细胞的分化和迁移、控制轴突的生长和导向,且与肿瘤的发生密切相关。相关研究表明Shh能缩减脑卒中大鼠的脑梗死体积并改善行为学预后。BACKGROUND：Many studies have showed that Sonic Hedgehog （Shh） signal pathway regulates the proliferation and differentiation of nerve cels, axon guidance and neural regeneration after brain injury. OBJECTIVE：To summarize the role of Shh signal pathway in embryonic development and post-natal nerve repair. METHODS：A computer-based retrieval was performed by the first author in PubMed and CNKI database to search related papers published from January 1980 to July 2015 using the keywords of “Shh signal pathway, embryogenesis, neural regeneration” in English and Chinese, respectively. Articles related to Shh signal pathway in embryonic cels differentiation, tissue development, post-natal neural regeneration, axon migration and tumor formation. A total of 38 relevant literatures were retrieved. RESULTS AND CONCLUSION： Recently, Shh signal pathway has become an issue of concern because this signal pathway is closely related with neural regeneration after brain injury. Shh is widely expressed in Hedgehog （Hh） family and plays a crucial role in embryogenesis and organogenesis. Shh is wel known to contribute to the patterning of neural tube system, regulate the proliferation and migration of progenitor cels, and control axonal growth and guidance. In addition, Shh is closely related to tumor formation. Studies have shown that Shh can reduce infarct volume and improve behavior prognosis of stroke rats.

关 键 词：组织构建 组织工程 胚胎发育 SHH 神经修复 细胞增殖 肿瘤 轴突 迁移导向 血管再生 

分 类 号：R318[医药卫生—生物医学工程]