常规与新型网孔羟基磷灰石修复唇腭裂的比较  

Comparison of conventional and new mesh hydroxyapatite in repair of cleft lip and palate

作　　者：余伟[1] 冯红超[1] 

机构地区：[1]贵州医科大学,贵州省贵阳市550004

出　　处：《中国组织工程研究》2015年第47期7629-7633,共5页Chinese Journal of Tissue Engineering Research

摘　　要：背景:尽管常规网孔羟基磷灰石具有一定的生物相容性和成骨诱导性,但在移植后不能被人体吸收,用于牙槽突裂的骨缺损充填时会影响上颌骨和尖牙的发育与萌出。目的:对比常规网孔羟基磷灰石与新型网孔羟基磷灰石复合骨修复牙槽突裂的效果。方法:将46例唇腭裂患者随机分为试验组与对照组,均按唇腭裂序列治疗安排,在行鼻部软组织缺损修复后,试验组采用新型网孔羟基磷灰石复合骨材料(羟基磷灰石与骨形态发生蛋白复合物)修复牙槽突裂,对照组采用常规网孔羟基磷灰石材料修复牙槽突裂。修复后6个月内,观察新形成骨组织平面至牙槽嵴顶端的垂直距离,从并发症情况、牙槽突裂形态大小、骨痂形成及材料吸收综合评定临床修复效果。结果与结论:试验组修复2,4,8,12,24周的新形成骨组织平面至牙槽嵴顶端的垂直距离均高于对照组(P<0.05),临床修复显效率和总有效率均高于对照组(P<0.05)。表明新型网孔羟基磷灰石复合骨材料修复牙槽突裂具有良好的成骨诱导性及生物相容性,并发症少且骨痂形成迅速。BACKGROUND：Despite regular mesh hydroxyapatite has certain biocompatibility and bone conductivity, it cannot be absorbed by human body after transplantation, and wil affect the growth and eruption of maxila and fangs when using for filing the injured alveolar cleft. OBJECTIVE： To compare the effect of conventional and new mesh hydroxyapatite composites in repair of alveolar cleft defects. METHODS： Totaly 46 patients with cleft lip and palate were randomly and evenly divided into test and control groups, and al were arranged according to cleft lip and palate sequence treatment. After nasal soft tissue defect repair, new mesh hydroxyapatite composite bone material （hydroxyapatite and bone morphogenetic protein compound）. Conventional mesh hydroxyapatite material was adopted in the test and control groups, respectively. Within 6 months after the repair, the vertical distance from the newly formed bone tissue plane to the top of alveolar ridge was observed. The clinical repair effect was comprehensively evaluated from the aspects of complications, alveolar cleft shape and size, calus formation and material absorption. RESULTS AND CONCLUSION： At 2, 4, 8, 12 and 24 weeks, the vertical distance from the newly formed bone tissue plane to the top of alveolar ridge in the test group was higher than that in the control group （P 〈 0.05）. The clinical repairing significant efficiency and total effective rate were al higher than those in the control group （P〈 0.05）. These results show that new mesh hydroxyapatite composite bone materials in the repair of alveolar cleft defects have good bone osteoinductivity and biocompatibility, rare complications and rapid calus formation.

关 键 词：生物材料 口腔生物材料 新型网孔羟基磷灰石 骨形态发生蛋白 唇腭裂序列治疗 牙槽突裂 

分 类 号：R318[医药卫生—生物医学工程]