骨关节病生物标志物及其应用价值的研究进展  

Research progress on the biomarkers in osteoarthritis

作　　者：杨磊[1] 刘欢[1] 郭雄[1] 

机构地区：[1]西安交通大学医学部公共卫生学院地方病研究所卫生部微量元素与地方病重点实验室教育部环境与疾病相关基因重点实验室,陕西西安710061

出　　处：《国外医学（医学地理分册）》2015年第4期259-262,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：国家自然科学基金资助项目(No.81472924)

摘　　要：骨关节病(osteoarthritis,OA)是一种以进行性关节软骨损害、软骨下骨修复、骨赘形成和滑膜炎症反应为特征的慢性关节疾病,目前对OA的诊断主要基于临床症状和放射线的改变,但对OA早期诊断和疾病进展的敏感性较差。OA的关节损害主要由于软骨退变和修复过程的不平衡,因此检测这些过程的生物标志物对于OA的早期诊断、监测疾病进展和治疗有重要意义。Osteoarthritis（OA）is a chronic joint disease characterized by progressive articular cartilage loss,subchondral bone repair,osteophyte formation,and synovial inflammation.At present,the diagnosis of OA is mainly based on clinical symptoms and radiographic changes,but their sensitivity to early diagnosis of OA and disease progression is poor.Since damage on joints is mainly caused by the imbalance of cartilage degeneration and repair process,to explore related biomarkers has important significance for the early diagnosis,monitoring of disease progression and treatment of OA.

关 键 词：骨关节炎 生物标志物 诊断 预后 

分 类 号：R684[医药卫生—骨科学]