2005～2012年寿光市人群HBsAg携带及乙肝发病情况调查  

Prevalence of hepatitis B surface antigen and incidence of hepatitis B,Shouguang city,2005-2012

作　　者：吉秀兰 张丽[2] 徐爱强[2] 

机构地区：[1]寿光市疾病预防控制中心,山东寿光262700 [2]山东省疾病预防控制中心,山东济南250014

出　　处：《预防医学论坛》2015年第12期885-887,共3页Preventive Medicine Tribune

基　　金：国家科技重大专项艾滋病和病毒性肝炎等重大传染病防治专项"山东省乙型病毒性肝炎防治综合示范区规模化现场流行病学和干预研究"(2009ZX10002-028)

摘　　要：目的了解寿光市健康人群HBsAg携带及乙肝发病状况,掌握乙肝感染和发病规律,为乙型肝炎免疫预防策略制定提供参考。方法通过调查7～12月龄严格按照0、1、6程序接种乙肝疫苗的婴儿,获得1岁以内婴儿乙肝感染数据,通过社区居民普查获得1岁以上人群乙肝感染数据,通过建立乙肝专病监测系统获得全市居民乙肝发病数据。结果 7～12月龄婴儿HBsAg阳性率为0.097%。1岁以上健康人群中,HBsAg总阳性率为2.72%,其中1～14和15～60岁人群乙肝表面抗原（Hepatitis B surface antigen,HBsAg）阳性率分别为0.82%和2.23%（P〈0.01）;男性和女性HBsAg阳性率分别为3.26%和2.24%（P〈0.01）。1～14和15～60岁人群乙肝发病率分别为0.13/万和3.32/万（P〈0.01）;男性和女性乙肝发病率分别为4.25/万和1.39/万（P〈0.01）。结论寿光市乙肝慢性感染和发病均以青壮年为主,乙肝仍是危害劳动力身体健康和生命安全的重要疾病,有必要开展成年乙肝疫苗接种。Objective To understand the prevalence of hepatitis B surface antigen（HBsAg）among the healthy population in Shouguang city and the incidence of hepatitis B,so as to provide reference for making immunization strategies.Methods HBsAg data for children 〈1 year old were obtained through serological surveys among infants aged 7-12 months who were fully vaccinated with HBV vaccines according to the 0,1,6month schedule.Prevalence of HBsAg for people aged 1year and older were estimated using data from community serological surveys.Hepatitis B surveillance data were used to estimate the incidence of hepatitis B in this population. Results HBsAg positive was observed in 0.097%of all children aged 7-12 months.The overall positive rate was 2.72% among healthy population aged 1year and older.The rate among children aged 1-14 years old and people aged 15-60 years was 0.82% and 2.23%（P〈0.01）.HBsAg positive rate was higher among males（3.26%）than in females（2.24%）（P〈0.01）.Hepatitis B incidence rate among people aged 15-60years（3.32/10^4）was significantly than the rate of children aged 1-14years（0.13/10^4,P〈0.01）.Male incidence（4.25/10^4）was significantly higher than that of females（1.39/10^4）. Conclusion In Shouguang city,young adults are the main population for HBsAg carriage and the onset of hepatitis B.Hepatitis B is still an important disease affecting productivity and threatening lives.Universal HBV vaccination among adults is necessary.

关 键 词：健康查体 HBSAG阳性率 乙肝发病率 成人乙肝疫苗接种 

分 类 号：R512.62[医药卫生—内科学]