白藜芦醇诱导细胞自噬在神经退行性疾病进展中的作用  

Effects of resveratrol-induced cellular autophagy in control of neurodegenerative diseases

作　　者：董雯[1] 王蓉[1] 

机构地区：[1]首都医科大学宣武医院中心实验室,北京脑重大疾病研究院阿尔茨海默病研究所,神经变性病教育部重点实验室,北京市老年病医疗研究中心,北京100053

出　　处：《药学学报》2016年第1期18-22,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81472007);北京市自然科学基金资助项目(7132044);首都卫生发展科研专项资助项目(2011-1001-02)

摘　　要：细胞自噬是清除自身异常蛋白和受损细胞器的过程,在调节细胞内环境稳态、细胞生长、发育和衰老以及疾病发生发展中起重要作用。自噬功能障碍与神经退行性疾病如阿尔茨海默病、帕金森病、亨廷顿病等密切相关。这些疾病的大脑神经元内大多存在特定的病理性蛋白的异常聚集。白藜芦醇对自噬具有调节作用,能促进自噬流的发生,有效清除易形成聚集体的病理性蛋白,对神经退行性疾病具有一定的防治潜力。本文综述了白藜芦醇调节细胞自噬方面的功能及在神经退行性疾病防治的应用。Cellular autophagy is a major degradative pathway for clearance of aggregate-prone proteins and damaged organelles. It plays an important role in regulating cellular homeostasis, cell growth and development, and disease development. Dysfunctional autophagy contributes to the pathology of various neurodegenerative diseases, such as Alzheimer＇s disease, Parkinson＇s disease and Huntington＇s disease, in which specific pathological protein accumulation occurs. A growing body of evidence suggests that resveratrol plays a significantly role in the regulation of autophagy and clearance of pathological proteins. Resveratrol is a potential drug for neurodegenerative diseases therapy. This review focuses on the effects of resveratrol on cellular autophagy and clinical application in the control of neurodegenerative diseases.

关 键 词：白藜芦醇 沉默信息调控因子1 去乙酰化 自噬 神经退行性疾病 聚集体 

分 类 号：R966[医药卫生—药理学]