自噬对抗肿瘤药物毒性的调控作用研究进展  

Study on the regulation of autophagy against anticancer drugs' toxicity

作　　者：娄小娥[1] 朱怡 何俏军[1] 

机构地区：[1]浙江大学药理毒理研究所,浙江省抗肿瘤药物临床前研究重点实验室,浙江大学药学院,浙江杭州310058

出　　处：《药学学报》2016年第1期29-32,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81473288);中国高等教育学会医学教育专业委员会药学教育研究会重点项目(201410);浙江省教育厅项目(Y201430737)

摘　　要：自噬是调节真核细胞生长、死亡、能量代谢的重要生物学机制。大量证据表明自噬参与多种抗肿瘤药物所导致的毒性,特别与心脏、肝脏及神经的损伤关系密切,目前对于自噬的调控作用是抗肿瘤药物毒性研究领域的热点。由于自噬对于心脏、肝脏和神经的功能是一把双刃剑,因此自噬对抗肿瘤药物毒性的调控作用是极其复杂的。这里作者将介绍自噬的基本概念并总结目前自噬对抗肿瘤药物毒性的调控作用。通过梳理这方面的研究成果将有助于抗肿瘤药物毒性的基础研究,并为抗肿瘤药物的毒性提供潜在的解决方案。Autophagy is a crucial biological process in eukaryotes, which is involved in cell growth, survival and energy metabolism. It has been confirmed that autophagy mediates toxicity of anticancer drugs, especially in heart, liver and neuron. It is important to understand the function and mechanism of autophagy in anticancer drugs-induced toxicity. Given that autophagy is a double-edged sword in the maintenance of the function of heart, liver and neuron, the autophagy-mediated toxicity are very complicated in the body. We provide a review on the concept of autophagy and current status about autophagy-mediated toxicity of anticancer drugs. The knowledge is crucial in the basic study of anticancer drugs-induced toxicity, and provides some strategies for the development of alleviating the toxicity of anticancer drugs.

关 键 词：自噬 抗肿瘤药物 心脏毒性 肝脏毒性 神经毒性 

分 类 号：R966[医药卫生—药理学]