小剂量多巴胺对烫伤大鼠休克期肠粘膜的保护作用  

The protective effects of small dose of dopamine on the intestinal mucosa of scalded rats in shock stage

作　　者：潘文东[1] 杨正文[1] 周明[1] 李木惠[1] 张道全[1] 

机构地区：[1]解放军第五十九中心医院烧伤科,开远661000

出　　处：《中华烧伤杂志》2002年第4期213-215,共3页Chinese Journal of Burns

摘　　要：目的　观察小剂量多巴胺对严重烫伤大鼠休克期肠粘膜机械屏障的保护作用。方法　大鼠预置心导管 ,30 %Ⅲ度烫伤后静脉复苏。观察大鼠常规治疗 (对照组 )和小剂量多巴胺 (3μg·kg-1·min-1)持续给药后 ,血清中二胺氧化酶 (DAO)、丙二醛 (MDA)及乳酸水平的变化 ,对肠道的病理学改变进行评分。　结果　多巴胺治疗组大鼠休克期一般情况明显好于对照组 ,小剂量多巴胺能显著降低严重烫伤大鼠血清中的乳酸、MDA、DAO水平 ,以伤后 3～ 12h明显 ;多巴胺治疗组大鼠回肠病理学评分明显优于对照组。　结论　小剂量多巴胺对严重烫伤大鼠休克期肠粘膜机械屏障有明显的保护作用。Objective To investigate the protective effects of small dose of dapamine on the intestinal mucosa of scalded rats in shock stage. Methods Wistar rats inflicted by 30% TBSA of Ⅲ degree scalding were employed as the model. The rats were pre placed with cardiac catheter before and were resuscitated intravenously after injury. The scalded rats were treated by routine (control) and small dose of dopamine (3 μg·kg -1 ·min -1 ), respectively. The changes of rat serum levels of diamine oxidase (DAO), malondiadehyde (MDA) and lactic acid (LA) were observed after treatment. And the pathomorphological changes of the intestine were scored.Results The general condition of the rats with dopamine treatment in shock stage was better than that in control group. The rat serum levels of MDA, LA and DAO decreased obviously, especially during 3 to 12 postburn hours (PBHs) after treatment by small dose of dopamine. The pathomorphological scoring of ileum in dopamine treating group was better than that in control. Conclusion The intestinal mucosa of severely scalded rats in shock stage could be well protected by small dose of dopamine.[

关 键 词：保护作用 多巴胺 肠粘膜 休克 烧伤 动物实验 

分 类 号：R644[医药卫生—外科学] R605.971[医药卫生—临床医学]