神经节苷脂联合还原型谷胱甘肽治疗新生儿缺氧缺血性脑病疗效观察  

Observation of Ganglioside Combined with Reduced Glutathione in Treatment of Neonatal HIE

作　　者：赵庭鉴[1] 张佩林[1] 韦定敏[1] 

机构地区：[1]桂林医学院附属医院,广西桂林541001

出　　处：《儿科药学杂志》2016年第1期17-19,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨神经节苷脂联合还原型谷胱甘肽治疗轻、中度新生儿缺氧缺血性脑病(HIE)的临床疗效。方法:将我院新生儿科2011年1月至2014年1月收治的200例HIE患儿采用随机数字表法分为观察组和对照组各100例,对照组采用胞二磷胆碱水解物联合神经节苷脂治疗,观察组在对照组治疗基础上加用还原型谷胱甘肽,比较两组患儿按疗程治疗后的临床疗效。结果:治疗前观察组和对照组的新生儿神经行为评分(NBNA)、脑白质区域低密度病灶CT值比较差异无统计学意义(P>0.05);治疗后观察组NBNA评分为(39.5±2.4)分,脑白质区域低密度病灶CT值为(19.5±1.8)Hu,对照组NBNA评分为(37.2±2.7)分,脑白质区域低密度病灶CT值(18.3±1.6)Hu,两组比较差异有统计学意义(P<0.05),且两组治疗后较治疗前均显著好转(P<0.05)。治疗前观察组和对照组的TNF-α、IL-6水平比较差异无统计学意义(P>0.05);治疗后观察组TNF-α为(86.7±12.4)pg/m L,IL-6为(97.6±15.9)pg/m L,对照组TNF-α为(119.4±11.5)pg/m L,IL-6为(138.5±17.2)pg/m L,两组比较差异有统计学意义(P<0.05),且两组均较治疗前显著好转(P<0.05)。观察组的肌张力、意识障碍、惊厥症状消失时间短于对照组(P<0.05)。观察组患儿的总有效率为94.0%,高于对照组的82.0%(P<0.05)。结论:还原型谷胱甘肽联合神经营养药物治疗轻、中度新生儿HIE较单用神经营养药物治疗的临床效果更显著。Objective： To explore the clinical curative effect of ganglioside combined with reduced glutathione for the treatment of mild to moderate neonatal hypoxic ischemic encephalopathy（ HIE）. Methods： Two hundreds cases of neonatal HIE in our hospital from January 2011 to January 2014 were randomly divided into observation group and control group with 100 cases in each group. The control group was given ganglioside,the observation group was given ganglioside combined with the reduced glutathione,then compared the clinical efficacy of the two groups after treatment. Results： There were no significant differences in neonatal neurological behavior scores（ NBNA） and the white matter of brain lesions of low density CT value before treatment in observation group and control group（ P〈0. 05）. After treatment,in observation group the NBNA was（ 39.5±2.4） points,the white matter of brain lesions of low density CT value was（ 19. 5 ±1. 8） Hu,in control group the NBNA was（ 37.2± 2.7） points,the white matter of brain lesions of low density CT value was（ 18.3±1.6） Hu,there were significant differences between two groups（ P〈0.05）,and there were significant improvements in two groups after and before treatment（ P〈0.05）. The levels of TNF-α,IL-6 had no significant difference in the observation group and the control group before treatment（ P〈0.05）. In observation group the level of TNF-α was（ 86.7±12.4） pg / m L,the level of IL-6 was（ 97.6±15.9） pg/m L,in control group the level of TNF-α was（ 119.4±11.5） pg/m L,the level of IL-6 was（ 138.5±17.2） pg/m L,there were significant differences between two groups（ P〈0. 05）,and there were significant differences in two groups before and after treatment（ P〈0.05）. The muscle tension,disturbance of consciousness,group convulsion symptoms disappear time in observation group were significantly shorter than the control group（ P〈0.05）. The total effective rate in observation group（ 94.0%） was higher tha

关 键 词：神经节苷脂 胞二磷胆碱水解物 还原型谷胱甘肽 新生儿 缺氧缺血性脑病 

分 类 号：R722.1[医药卫生—儿科]