维格列汀联合二甲双胍对2型糖尿病血清氧化物质水平的影响  

Effect of vildagliptin combined with metformin on content of oxidative related substances in patients with type 2 diabetes mellitus

作　　者：辛彩虹[1] 李峥[2] 闫吉[3] 王楠[3] 旷劲松[1] 

机构地区：[1]辽宁省沈阳市第四人民医院内分泌科,110032 [2]辽宁中医药大学附属医院心内科,沈阳110032 [3]辽宁省沈阳市第四人民医院检验科,110032

出　　处：《检验医学与临床》2016年第1期24-26,共3页Laboratory Medicine and Clinic

基　　金：辽宁省沈阳市科技局课题(F11-262-9-25)

摘　　要：目的观察维格列汀联合二甲双胍对2型糖尿病患者体内氧化相关物质水平的影响。方法选取2013年3月至2014年3月于辽宁省沈阳市第四人民医院内分泌科住院的二甲双胍单药控制不佳的2型糖尿病患者100例,分为对照组(50例)和观察组(50例)。对照组使用二甲双胍治疗,观察组为二甲双胍与维格列汀联合治疗,连续治疗24周后,比较两组患者治疗前后血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、活性氧类物质(ROS)及空腹血糖(FBG)水平,并比较两组不良反应发生情况。结果治疗24周后,对照组患者外周血清GSH-PX、SOD水平低于观察组,差异有统计学意义(P<0.05);对照组患者外周血清ROS、MDA、FBG水平高于观察组,差异有统计学意义(P<0.05);两组不良反应率比较,差异无统计学意义(P>0.05)。结论在二甲双胍基础上给予维格列汀能通过升高外周血GSH-PX、SOD水平与降低ROS、MDA水平来减轻2型糖尿病患者氧化应激损伤,且不良反应较少。Objective To observe the effect of vildagliptin combined with metformin on oxidative related sub- stances in patients with type 2 diabetes mellitus（T2DM）. Methods 100 T2DM inpatients with poor control by single metformin in the endocrinology department of the Shenyang Municipal Fourth People＇s Hospital from March 2013 to March 2014 were selected and divided into the observation group （n = 50） and the control group （n = 50）. The control group was given metformin,while the observation group was treated with metformin combined with vildagliptin. The two groups were treated for 24 weeks. The serum MDA, SOD, GSH-PX, ROS and FBG levels were compared between the two groups. Meanwhile the adverse reactions were compared between the two groups. Results The serum GSH-PX,SOD levels after 24-week treatment in the control were lower than those in the observation group, the difference was statistically significant（P〈0.05）. The peripheral serum ROS, MDA and FBG levels in the control group were higher than those in the observation group,the difference was statistically signifieant（P〈0.05）. The occurrence rate of adverse reactions had no statistical difference between the two groups（P〉0.05）. Conclusion On thebasis of metformin, giving vildagliptin can effectively alleviate the oxidative stress damage in the patients with T2DM through elevating the peripheral blood GSH-PX, SOD levels and reducing the ROS and MDA levels,moreover has few adverse reactions.

关 键 词：维格列汀 2型糖尿病 超氧化物歧化酶 谷胱甘肽过氧化物酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]