扶正通络法联合舒利迭防治儿童哮喘临床观察  

Effect of Strengthen Health and Tongluo Theory Combined with Seretide in Preventing and Treating Children with Asthma

作　　者：施品英[1] 朱金凤[1] 沈鸣[1] 

机构地区：[1]江苏省南通市中医院,江苏南通226001

出　　处：《辽宁中医药大学学报》2016年第1期21-23,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察运用扶正通络法(朱氏加味定喘散)联合舒利迭吸入防治儿童哮喘的临床疗效及其对免疫功能的影响。方法:将100例哮喘患儿随机分成治疗组和对照组各50例,两组均吸入舒利迭50μg/100μg,12 h1次,治疗组同时予朱氏加味定喘散口服,两组疗程均为3个月。观察两组患儿临床疗效、治疗前后哮喘控制测试(ACT评分)、可溶性白细胞介素4(IL-4)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)的变化。结果:治疗组总有效率96.00%,对照组为84.00%,治疗组明显高于对照组(P<0.05)。两组治疗后ACT评分均较本组治疗前升高,TNF-α及IL-4降低(P<0.01),且治疗组优于对照组(P<0.05或P<0.01)。治疗组治疗后外周血IFN-γ较治疗前升高(P<0.01)。结论:该研究证实朱氏加味定喘散加减口服联合舒利迭吸入能改善哮喘患儿临床症状,调节免疫功能,有效防治哮喘。Objective：To observe the effect of strengthen health and Tongluo theory（Zhushi Jiawei Dingchuan Powder）combined with seretide inhalation in preventing and treating children with asthma and to study its influence on immune function. Methods：All 100 cases of children with asthma were randomized into two groups：50 in treatment group and 50 in control group.Both group were treated with seretide inhalation 50 μg/100μg q12 h for 3 months,based on which,the treatment group were treated with Zhushi Jiawei Dingchuan Powder. The effect and changes in ACT scores of both groups were observed,and serum IL-4,TNF-α,IFN-γ were determined before and after treatment. Results：The total effective rate of the treatment group and control group was 96.00% and 84.00% respectively,with significant difference（P〈0.05）. After treatment the levels of TNF-α and IL-4 decreased,ACT scores increased（P〈0.01）. The treatment group was superior to the control group in increase of ACT scores and decrease of TNF-α and IL-4（P〈0.05 or P〈0.01）. The levels of IFN-γ in treatment group were significantly improved than before treatment（P〈0.01）. Conclusion：Oral Zhushi Jiawei Dingchuan Powder combined with seretide inhalation can improve symptoms in children with asthma,regulate immunity,and its good at preventing and treating asthma.

关 键 词：扶正通络 舒利迭 儿童 支气管哮喘 

分 类 号：R256.12[医药卫生—中医内科学]