熊果酸自微乳冻干制剂体外评价  

In Vitro Evaluation of Ursolicacid Self-microemulsifying Preparations After Freeze-drying

作　　者：孙丹丹[1] 闫雪生[1] 徐新刚[1] 于蓓蓓[1] 生立嵩[1] 

机构地区：[1]山东省中医药研究院,山东济南250014

出　　处：《辽宁中医药大学学报》2016年第1期56-59,共4页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：山东省科技发展计划项目(2011GSF11902)

摘　　要：目的:制备熊果酸自微乳冻干制剂并进行体外评价。方法:制备熊果酸自微乳冻干制剂,考察其形态、粒径分布、Zeta电位、p H值、电导率、折光率、黏度、稳定性及体外释放度等。结果:熊果酸自微乳冻干制剂在透射电镜下成球状或类球状,平均粒径为34.5 nm,Zeta电位为-9.72,p H值为5.72,电导率为16.2μs·cm^(-1),折光率为1.3354,黏度为2.4 m Pa·s,冻干制剂在6个月内稳定性良好,与药物溶液相比,熊果酸自微乳制剂在体外具有一定缓释效果。结论:熊果酸自微乳冻干制剂物理和化学稳定性良好,体外释药表明熊果酸自微乳制剂呈现一定的缓释效果。Objective：To investigate the preparation and in vitro evaluation of Ursolicacid（UA）self-microemulsion after freeze-drying. Methods：The quality of the UA self-microemulsion was evaluated after freeze-drying. Including partical size and its distribution,configuration,Zeta potential,p H,viscosity,refractive,conductivity,releasing characteristic in vitro and stability. Results：The selfmicroemulsion was spheroidal shape through observing by transmission electron microscopy,the mean partical size was 34.5 nm,the Zeta potential was-9.72,the p H value was 5.72,the conductivity was 16.2 μs·cm^（-1）,the refractive was 1.3354,the viscosity was 2.4 m Pa·s,the stability test showed that the properties of the preparation were stable in six mounths after freeze-drying,and releasing characteristic in vitro showed prolonged release characteristic. Conclusion：The stability experiments indicate that the physical and chemical stability of the UA self-microemulsion is favorable after freezedrying. Comparing with UA solution,UA self-microemulsion exhibited a certain delayed release profile.

关 键 词：熊果酸 自微乳 体外评价 

分 类 号：R284[医药卫生—中药学]