痤疮患者外周血淋巴细胞亚群的研究  

Research of peripheral blood lymphocyte subpopulation in patients with acne

作　　者：韩莹[1] 程欣[1] 

机构地区：[1]辽宁省沈阳市第七人民医院皮肤科,110003

出　　处：《中国现代药物应用》2016年第1期21-22,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨痤疮患者的免疫功能变化。方法应用流式细胞仪分析检测80例痤疮患者(痤疮组)外周血中的淋巴细胞亚群,并与80例正常人(正常组)进行比较。结果与正常组相比,痤疮组CD3+T细胞升高,CD3+CD4+T细胞降低,CD3+CD8+T细胞升高,CD3-CD19+细胞降低,CD3-CD16+56+NK细胞降低,差异均有统计学意义(P<0.05)。结论免疫功能的紊乱是痤疮患者发病的一个重要机制,在痤疮的发生、发展过程中可能起到重要的作用。Objective To investigate changes of immunologic function in patients with acne. Methods Flow cytometric analysis was applied to detect peripheral blood lymphocyte subpopulation in 80 patients with acne（acne group）, and the result was compared with that of 80 healthy people（healthy group）. Results Comparing with healthy group, acne group had increased CD3＋ T cell, CD3＋CD8＋ T cell, and decreased CD3＋CD4＋ T cell, CD3-CD19＋ cell, and CD3-CD16＋56＋ NK cell. The difference had statistical significance（P〈0.05）. Conclusion As a key pathogenesis of acne, immune dysfunction plays an important role in occurrence and development of acne.

关 键 词：痤疮 淋巴细胞亚群 流式细胞分析法 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]