风湿祛痛胶囊的抗炎作用研究  

Study on Anti-inflammatory Effects of Fengshi Qutong Capsule

作　　者：孙璠璠 李萍 朱志杰 王雨辰[1] 张月[1] 卢泽原 于晓风[1] 睢大筼[1] 

机构地区：[1]吉林大学药学院药理教研室,长春130021 [2]通化金马药业集团,吉林通化134000

出　　处：《中国药房》2016年第1期26-28,共3页China Pharmacy

基　　金：吉林省科技发展计划项目(No.20130306048HJ)

摘　　要：目的：研究风湿祛痛胶囊的抗炎作用。方法：分别取60只大鼠随机均分为模型（0.5%羟甲基纤维素钠）组、万通筋骨片（对照药物,0.3 g/kg）组和风湿祛痛胶囊低、中、高剂量（0.25、0.5、1.0 g/kg）组,ig给药,每天1次,连续7 d;进行角叉菜胶足跖肿胀实验、棉球肉芽肿实验,检测大鼠足跖肿胀率、棉球肉芽肿指数及脏器指数。分别取60只小鼠随机均分为模型（0.5%羟甲基纤维素钠）组、万通筋骨片（对照药物,0.4 g/kg）组和风湿祛痛胶囊低、中、高剂量（0.3、0.6、1.2 g/kg）组,ig给药,每天1次,连续7 d;通过测定小鼠腹腔液中伊文氏蓝的含量考察各组小鼠腹腔毛细血管通透性。结果：与模型组比较,风湿祛痛胶囊中、高剂量组大鼠在致炎后1~6 h足趾肿胀率、棉球肉芽肿指数显著降低（P〈0.05或P〈0.01）;各给药组小鼠腹腔毛细血管的通透性均无明显变化（P〉0.05）;与万通筋骨片组比较,给药组各指标均无明显差异（P〉0.05）。结论：风湿祛痛胶囊具有一定的抗炎作用。OBJECTIVE：To study the anti-inflammatory effects of Fengshi qutong capsule. METHODS：Each experiment took60 rats,and then the rats were randomly divided into model（0.5% sodium carboxymethylcellulose）group,Wantong jingu tablet group（reference drug,0.3 g/kg）and Fengshi qutong capsule low-dose,medium-dose and high-dose groups（0.25,0.5,1.0 g/kg）;they were given relevant medicine intragastrically once a day for consecutive 7 days. The rate of paw swelling,cotton ball granuloma index and organ index in rats were determined by carrageenin paw swelling test and cotton ball granuloma test. 60 mice were randomly divided into model group（0.5% sodium carboxymethylcellulose）,Wantong jingu tablet group（reference drug,0.4 g/kg）and Fengshi qutong capsule low-dose,medium-dose and high-dose groups（0.3,0.6,1.2 g/kg）;they were given relevant medicine intragastrically once a day for consecutive 7 days. The content of Evan＇s blue in abdominal cavity was determined to investigate the permeabilities of blood capillary in abdominal cavity of mice. RESULTS：Compared with model group,the rate of paw swelling and cotton ball granuloma index in rats of Fengshi qutong capsule medium-dose and high-dose groups decreased significantly 1-6 h after inflammation induction（P〈0.05 or P〈0.01）;the permeability of blood capillary in abdominal cavity of the mice had no significant change in treatment groups（P〉0.05）;compared with Wantong jingu tablet group,there was no significant difference in each indicator of treatment groups（P〉0.05）. CONCLUSIONS：Fengshi qutong capsule has certain anti-inflammatory effects.

关 键 词：风湿祛痛胶囊 抗炎 足跖肿胀率 棉球肉芽肿指数 毛细血管通透性 大鼠 小鼠 

分 类 号：R285[医药卫生—中药学]