骨疏灵颗粒不同配伍对淫羊藿苷含量的影响  

Effects of the Compatibility of Gushuling Granules on the Icariin Content

作　　者：俞吉[1,2] 朱瑞[2] 董妍君[2] 朱裕林[3] 桑冉[3] 陈卫东[2] 

机构地区：[1]淮南市朝阳医院药剂科,安徽淮南232001 [2]安徽中医药大学药学院,合肥230031 [3]蚌埠医学院第一附属医院药剂科,安徽蚌埠233004

出　　处：《中国药房》2016年第1期79-82,共4页China Pharmacy

基　　金：安徽省自然科学基金资助项目(No.1208085MH127)

摘　　要：目的:研究骨疏灵颗粒方中各药材配伍对淫羊藿苷含量的影响。方法:以组方中黄芪、牛膝、牡蛎的配伍为因素,配伍后处方煎煮液中淫羊藿苷总含量为指标,采用正交试验法考察不同药材配伍对淫羊藿苷含量的影响;测定含淫羊藿和黄芪配伍的煎液的p H及沉淀中的淫羊藿苷含量。结果:黄芪的配伍对方中淫羊藿苷含量的影响具有统计学意义(P<0.05),牡蛎、牛膝配伍则无影响(P>0.05),黄芪、牡蛎、牛膝对淫羊藿苷含量的影响不存在两两交互作用;各配伍煎液p H无明显差异;所有淫羊藿与黄芪的配伍均可产生沉淀,且沉淀中淫羊藿苷含量升高。结论:淫羊藿配伍黄芪煎煮后可形成沉淀,由此降低煎液中淫羊藿苷的含量,此变化与煎液的p H无相关性。OBJECTIVE：To study the effects of the compatibility of medicinal materials on the content of icariin in Gushuling granules formula. METHODS：The effects of the compatibility of medicinal materials on the content of icariin was investigated by orthogonal design with the compatibility of Astragalus membranaceus,Achyranthes bidentata and Concha ostreae as factors,using the content of icariin in decoction as index. The p H of mixture of Epimedium brevicornu and A. membranaceus,and the content of icariin in precipitation were determined. RESULTS：The effects of the compatibility of A. membranaceus on the content of icariin had statistical significance（P〈0.05）;the compatibility of A. bidentata and C. ostreae had no statistical significance（P〉0.05）;the interactions between two medicinal materials had not been found;the p H of the mixtures had no significant difference;the compatibility of E. brevicornu and A. membranaceus produced precipitation,and the content of icariin in precipitation increased. CONCLUSIONS：The compatibility of E. brevicornu and A. membranaceus can produce precipitation,so as to decrease the content of icariin in decoction,which is not influenced by p H value of decoction.

关 键 词：骨疏灵颗粒 黄芪 牡蛎 牛膝 配伍 淫羊藿苷 高效液相色谱法 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]