5-氨基酮戊酸光动力疗法治疗面部扁平疣疗效观察  

Clinical observation of topical photodynamic therapy for facial flat warts

作　　者：徐圣经[1] 丁克云[1] 赵志国[1] 孙彩虹[1] 张彩萍[1] 杜素萍[1] 

机构地区：[1]江苏大学附属人民医院皮肤科,江苏镇江212002

出　　处：《中国美容医学》2015年第23期49-51,共3页Chinese Journal of Aesthetic Medicine

基　　金：镇江市科技计划指导性项目(FZ2010047)

摘　　要：目的:探讨5-氨基酮戊酸光动力疗法(5-aminolevulinic acid photodynamic therapy,ALA-PDT)治疗面部扁平疣的临床疗效。方法:将入选的患者随机分为两组。治疗组:28例,用5-氨基酮戊酸光动力疗法治疗,1次/周,共3周;对照组:30例,外擦1%喷昔洛韦乳膏,2次/d,同时外用0.1%维A酸霜,每晚1次。疗程结束后判定疗效并随访3个月。结果:治疗组有效率、痊愈率分别为96.43%、89.29%,对照组有效率、痊愈率分别为63.34%、36.67%,两组疗效比较差异有统计学意义(P<0.05)。随访3个月,治疗组复发率12.00%,对照组复发率36.34%,治疗组复发率低于对照组,差异有统计学意义(P<0.05)。结论:ALA-PDT是目前比较安全、高效的治疗扁平疣的方法。Objective To observe the effect of 5-aminolevulinic acid photodynamic therapy for facial flat warts. Methods 58 patients with facial flat warts were randomly divided into two treatment groups,the treatment group with 28 patients were treated with 5-aminolevulinic acid photodynamic therapy once a week for three weeks in total,while 30 cases in the control group received combined topical treatment of penciclovir cream twice a day and 0.1% all-trans retinoic acids cream once a day for four weeks. Results The total effective rates and cure rates of treatmet group was 96.43, 89.29% respectively,while the control group was 63.34%,36.67% respectively.There was a significant difference between the two groups（P〈0.05）.The recurrence rate of treatment group was 12% while the control group was 36.34% in the follow-up. Conclusion Topical 5-aminolevulinic acid ohotodvnamic theraDv for facial flat warts has hiah safetv and sianificant effect.

关 键 词：光动力疗法 扁平疣 5-氨基酮戊酸 维A酸 喷昔洛韦 

分 类 号：R752.52[医药卫生—皮肤病学与性病学]