红细胞及血小板体积分布宽度、生长分化因子-15与心力衰竭患者预后的相关性  

Correlation of RDW,PDW and GDF-15 with prognosis of heart failure

作　　者：许锦荣[1] 陈玲[1] 凌云[1] 苏成标 黎明[2] 黄石安[2] 

机构地区：[1]广东医学院第二附属医院心血管内科,广东湛江524003 [2]广东医学院附属医院心血管内科,广东湛江524001

出　　处：《广东医学》2015年第23期3643-3645,共3页Guangdong Medical Journal

基　　金：广东省湛江市科技计划项目(编号:2069999);广东省企业技术研发与升级改造专项资金项目(编号:2013B021800108)

摘　　要：目的探讨红细胞分布宽度(RDW)、血小板体积分布宽度(PDW)、生长分化因子-15(GDF-15)与心力衰竭患者预后的相关性。方法选取心力衰竭患者100例作为观察组,选择100例同期住院的非心力衰竭心脏病患者作为对照组,检测两组RDW、PDW、GDF-15与氨基末端脑钠肽前体(NT-pro BNP)及左室射血分数(LVEF)的关系,评估其相关性。结果观察组LVEF、NT-pro BNP、RDW、PDW及GDF-15明显高于对照组,两组比较差异具有统计学意义(P<0.05)。观察组RDW、PDW及GDF-15与LVEF、NT-pro BNP呈明显相关性(P<0.05)。结论 RDW、PDW及GDF-15水平与心力衰竭患者心功能各项指标关系密切,对于充血性心力衰竭患者的病情评估、疗效监测和预后判断均具有重要的临床意义。Objective To investigate the correlation of RDW,PDW and GDF- 15 with prognosis of heart failure. Methods One hundred cases with heart failure were enrolled and assigned to the observation group,while 100 contemporary in- patient cases without heart failure were collected and assigned to the control group. LVEF,NT- pro BNP,RDW,PDW and GDF- 15 were measured and their correlation was evaluated. Results The levels of LVEF,NT- pro BNP,RDW,PDW in the observation group were higher than those in the control group（ P〈0. 05）. Levels of RDW,PDW and GDF- 15 was significantly correlated with levels of LVEF and NT- pro BNP in the observation group（ P〈0. 05）.Conclusion Levels of RDW,PDW and GDF- 15 was closely correlated with indicators of heart function in heart failure cases,which are of important clinical significance in evaluation of disease severity,monitoring of treatment effect and assessment of prognosis in CHF patients.

关 键 词：红细胞体积分布宽度 血小板体积分布宽度 生长分化因子-15 心力衰竭 相关性 

分 类 号：R259.416.1[医药卫生—中西医结合]