Structural and functional connectivity in traumatic brain injury  

作　　者：Hui Xiao Yang Yang Ji-hui Xi Zi-qian Chen 

机构地区：[1]Center of Medical Imaging,Fuzhou General Hospital of Nanjing Military Command [2]Department of Medical Imaging,Dongfang Hospital,Xiamen University [3]Department of Emergency,Fuzhou General Hospital of Nanjing Military Command

出　　处：《Neural Regeneration Research》2015年第12期2062-2071,共10页中国神经再生研究（英文版）

基　　金：supported by a grant from the Medical Scientific Research Programs of Nanjing Military Command,No.14MS122

摘　　要：Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms.However,the neurobiological mechanisms underlying specific impairments are not fully understood.Advances in neuroimaging techniques（such as diffusion tensor imaging and functional MRI）have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease.The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks.Using these powerful neuroimaging approaches,changes at the microstructural level can be detected through regional and global properties of neuronal networks.Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury,mainly focusing on structural and functional connectivity.Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury.These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae,as well as predicting outcome and prognosis.Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms.However,the neurobiological mechanisms underlying specific impairments are not fully understood.Advances in neuroimaging techniques（such as diffusion tensor imaging and functional MRI）have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease.The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks.Using these powerful neuroimaging approaches,changes at the microstructural level can be detected through regional and global properties of neuronal networks.Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury,mainly focusing on structural and functional connectivity.Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury.These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae,as well as predicting outcome and prognosis.

关 键 词：nerve regeneration traumatic brain injury brain trauma CONNECTIVITY diffusion tensorimaging resting-state fMRI CONNECTOME default mode network COGNITION neural regeneration 

分 类 号：R651.1[医药卫生—外科学]