阿仑膦酸钠联合钙尔奇D预防帕金森患者骨质疏松及髋骨骨折的疗效观察  

THE CLINICAL OBSERVATION OF PREVENTION PARKINSON'S PATIENTS WITH OSTEOPOROSIS AND HIP FRACTURES BY ALENDRONATE SODIUM AND CALTRATE D

作　　者：施静静[1] 刘毅[1] 陈涛[1] 宋学萍[2] 龚家明[1] 胡德容 

机构地区：[1]安康市中心医院,陕西安康725000 [2]广州市白云区人民医院,广东广州510515

出　　处：《现代医院》2015年第12期59-61,共3页Modern Hospitals

基　　金：广东省科技计划项目(编号:20120314)

摘　　要：目的 探讨应用阿仑膦酸钠联合钙尔奇D预防帕金森患者骨质疏松及髋骨骨折的临床疗效。方法 按纳入标准收集安康市中心医院2010年9月~2012年9月门诊及住院部帕金森患者,随机分为对照组、钙尔奇D组、联合组。对比3组患者的年龄、性别、体重指数、帕金森病程有无差别。检测3组患者股骨颈、转子、转子间、整髋、Ward区5个区域的骨密度值及其平均值,并进行对比分析。对3组患者进行持续3年的跟踪随访,记录随访期间髋部骨折的发生情况,对比不同组骨折发病率的差别。结果 共收集门诊及住院部共帕金森患者364例,其中对照组120例、钙尔奇D组123例、联合组121例。3组患者的年龄、性别、体重指数、帕金森病程及Wester评分均无显著性差异（P〉0.05）。3组患者在入组时,股骨颈、转子、转子间、整髋、Ward区5个区域的骨密度值及总平均值均无显著性差异（P〉0.05）;钙尔奇D组入组后6个月、1年,转子间、整髋的骨密度值及总平均值高于对照组（P〈0.05）,入组后2年转子间、整髋、Ward区及总平均值高于对照组（P〈0.05）;联合组入组后6个月、1年、2年,股骨颈、转子、转子间、整髋、Ward区5个区域的骨密度值及总平均值均有显著性差异（P〈0.05）;联合组入组后6个月、1年股骨颈、转子、Ward区域的骨密度值及总平均值有显著性差异（P〈0.05）,入组后2年股骨颈、转子、Ward区域、整髋及总平均值有显著性差异（P〈0.05）。骨折发生率：联合组骨折发生率低于对照组和钙尔奇D组,有显著性差异（P〈0.05）,钙尔奇D组骨折发生率与对照组无差异（P〉0.05）。结论 应用阿仑膦酸钠联合钙尔奇D能有效地预防帕金森患者骨质疏松,并能降低髋骨骨折的发生率。Objective To discuss the clinical effects of prevention Parkinson＇s patients from osteoporosis and hip fractures by Alendronate sodium and Cahrate D. Method We collected the outpatient and inpatient Parkinson＇s patients according to the inclusion criteria from September 2010 to September 2012. All the cases were divided into three groups randomly： control group （OB group） , calcium group D （GD group） , and joint group （LH GROUP）. Compared the age, sex, body mass index and Parkinson＇s disease progression between three groups. We detected and analyzed the bone mineral density （BMD） of the three groups at hip femoral neck, troehanter, intertrochanterie, whole hip, Ward area and the average of the five regional above. All the cases were following - up continued 3 years, and the accidents of hip fracture were recorded. Result 64 Parkinson＇s patients were collected, including 120 cases in OB group,123 cases in GD group,121 cases in LH group. The age, sex, body mass index and Parkinson＇s disease progression of three groups were no significantly different, P 〉 0.05. The BMD of the three groups at hip femoral neck, trochanter, intertrochanteric, whole hip, Ward area and the average of the five regional above were no signifi- cantly different in the beginning, P 〉 0.05. The BMD of intertrochanteric, whole hip and the average in GD group were higher than OB group after 6 months, 1 years （P 〈 0.05 ）. And in the GD group, the BMD of intertrochanteric, whole hip, Ward area and the average were higher than OB group （ P 〈 0. 05 ） after 2 years. The BMD of hip femoral neck, trochanter, intertrochanteric, whole hip, Ward area and the average in LH group were higher than OB group （ P 〈 0.05 ） after 6 months, 1 year, and 2years. The BMD of hip femoral neck, trochanter, Ward area and the average in LH group were higher than OB group （ P 〈 0.05 ） after 6 months, 1 year. In LH group, the BMD of hip femoral neck, trochanter, whole hip, Ward area and the average were higher than GD

关 键 词：帕金森病 髋骨骨折 骨密度 阿仑膦酸钠 钙尔奇D 

分 类 号：R681[医药卫生—骨科学]