光敏感两亲聚合物的光异构化行为及其在可控释放中的应用  

Photo-Isomerization Behaviors of the Amphiphilic Polymer with Photo-Responsibility and Its Application in Control Release

作　　者：李相晔[1] 王宛洛 徐首红[1] 刘洪来[1] 

机构地区：[1]华东理工大学化学系,结构可控先进功能材料及其制备教育部重点实验室,上海200237

出　　处：《功能高分子学报》2015年第4期337-345,共9页Journal of Functional Polymers

基　　金：国家自然科学基金(21276074)

摘　　要：利用偶氮苯(AZO)的光敏感和疏水性、聚乙二醇(PEG)的亲水性,制备了中间疏水、两端亲水的光敏感两亲聚合物(PEG-AZO-PEG)。利用紫外-可见吸收光谱研究了PEG-AZO-PEG在不同微环境中的光异构化行为。用溶剂蒸发法获得了PEG-AZO-PEG的光敏感胶束,考察了该胶束对疏水分子布洛芬的负载和光控释放。结果表明:通过调节溶剂种类、pH、聚合物溶液浓度可改变PEG-AZO-PEG的异构化速率;紫外光照射有效增大了布洛芬的累积释放率;此外,布洛芬的累积释放率随着体系pH的增加而增大。Based on the photo-isomerization and hydrophobic property of azobenzene（AZO）,as well as the hydrophilicity of polyethylene glycol（PEG）,a novel kind of amphiphilic polymer（PEG-AZO-PEG）with photo-responsibility was synthesized.The photo-isomerization behaviors of PEG-AZO-PEG in different conditions were studied through UV-Vis spectra.The photoresponsive micelles of PEG-AZO-PEG were prepared by solvent evaporation method.The load and release behaviors of micelles were studied using ibuprofen as model hydrophobic molecules.Results show that the isomerization rate can be regulated by tailoring the kind of solvent,pH value and the concentration of PEG-AZO-PEG.The accumulated release amount of ibuprofen increases remarkably under UV irradiation due to the disassembly of micelles.Besides,the accumulated release amount increases with the increase of pH value.

关 键 词：偶氮苯 两亲性 光致异构化 自组装 可控释放 

分 类 号：O63[理学—高分子化学]