高选择性拆分α-苯乙醇的研究  

Study of high selectivity for the resolution of optically active α-phenylethanol

作　　者：朱成峰[1] 邓威力 王晓阳[1] 王云飞[1] 李有桂[1] 

机构地区：[1]合肥工业大学化学与化工学院,安徽合肥230009

出　　处：《合肥工业大学学报（自然科学版）》2015年第12期1678-1682,共5页Journal of Hefei University of Technology：Natural Science

基　　金：国家自然科学基金资助项目(21401037);安徽省自然科学基金资助项目(1508085QB26);中央高校基本科研业务费专项资金资助项目(JZ2014HGBZ0075)

摘　　要：手性α-苯乙醇是合成多种手性药物的重要中间体,文章设计了一种反应条件温和、产率高、选择性优的拆分手性α-苯乙醇的方法。该方法将外消旋的α-苯乙醇与邻苯二甲酸酐作用生成邻苯二甲酸单酯,然后以手性α-苯乙胺为手性拆分剂,三乙胺为拆分助剂,在乙醇和丙酮的混合溶剂中进行二次重结晶,从而获得产率为80.5%、对映体过量(enantiomeric excess,ee)值高达99.1%的手性α-苯乙醇。Chiral ocphenylethanol is an important intermediate of chiral drugs. In this paper, a method to separate racemic a-phenylethanol was designed, which was mild in reaction, high in yield and good in selectivity. The racemic ocphenylethanol reacted with phthalic anhydride to generate phthalic acid monoester that was separated by chiral α-phenethylamine and triethylamine, and then chiral α-pheny- lethanol with higher enantiomeric excess（ee） up to 99.1% could be obtained by recrystallization from ethanol and acetone, and the yield was 80. 5

关 键 词：化学拆分 手性 Α-苯乙醇 Α-苯乙胺 三乙胺 

分 类 号：O621.44[理学—有机化学]