中药支原清方治疗儿童肺炎支原体肺炎的疗效观察及对T淋巴细胞亚群的影响  

Zhi Yuan Qing treatment for children with Mycoplasma pneumoniae pneumonia:observation on the curative effect and its influence on Tlymphpcyte subsets

作　　者：白月双[1] 施益农[1] 朱越[1] 高艳[1] 朱树丽[1] 

机构地区：[1]江苏省第二中医院儿科,南京210017

出　　处：《中国中西医结合儿科学》2015年第6期600-603,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：江苏省卫生厅科研课题基金支持项目(LZ13098)

摘　　要：目的观察中药验方"支原清"对儿童肺炎支原体肺炎的临床疗效及对T淋巴细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)数值变化的影响。方法 2013-07/2015-03选择江苏省第二中医院儿科收治肺炎支原体肺炎患儿60例,随机分为观察组和对照组各30例,观察组采用中药"支原清"口服治疗21d,对照组用阿奇霉素颗粒联合急支糖浆口服液治疗21d。治疗结束后比较两组患儿的临床疗效,并观察治疗前后两组患儿血清T淋巴细胞亚群数值的变化。结果两组总有效率均为100%(30/30),但观察组临床控制率为86.66%(26/30),对照组临床控制率为40%(12/30),两组比较差异有统计学意义(P<0.01);观察组外周血CD3^+、CD4^+细胞明显高于对照组,CD8^+细胞低于对照组,两组比较差异有统计学意义(P<0.01);观察组外周血CD4^+/CD8^+数值高于对照组,两组比较差异有统计学意义(P<0.05)。结论中药验方"支原清"治疗儿童肺炎支原体肺炎安全有效,在T淋巴细胞亚群数值的调节中作用明显,有利于提高细胞免疫功能。Objective To observe the effect of TCM prescriptions of ＂ Zhi Yuan Qing＂ on Mycoplasma pneumoniae pneumonia in children and its influence on the T lymphocyte subsets（CD3＋、CD4＋、CD8＋、CD4＋/CD8＋）value changes.Methods Totally 60 cases of children with Mycoplasma pneumoniae pneumonia were randomly divided into treatment group and control group.The treatment group was treated with Zhi Yuan Qing orally for 21 days.The control group was given azithromycin granules and Jizhi Syrup orally for 21 days,Compare clinical curative effect of two groups,and observe the changes of serum value of T lymphocyte subsets before and after the treatment.Results In treatment group and control group,total effective rate was 100%;the clinical control rate was 86.66%in treatment group,and 40%in control group,which showed extremely significant difference（P〈0.01）.In the treatment group CD3＋and CD4＋cells in peripheral blood were significantly higher than in the control group,with significant difference（P〈0.05）.In the treatment group the peripheral blood CD8＋cells were lower than in the control group,showing significant difference（P〈0.05）.Conclusion Traditional Chinese medicine prescription of ＂ Zhi Yuan Qing＂ for children with Mycoplasma pneumoniae pneumonia is safe and effective,and the regulation of T lymphocyte subgroup level is better,which helps to improve the cellular immune function.

关 键 词：肺炎 肺炎 支原体 支原清/治疗应用 T淋巴细胞亚群 细胞免疫 儿童 

分 类 号：R563.1[医药卫生—呼吸系统]