^(18)F-FDG PET-CT全身显像在不明原因肝转移癌中查找原发灶的临床应用  

Searching for the unknown primary lesion of hepatic metastatic carcinoma

作　　者：李月凯[1] 李凤彩[1] 刘剑峰[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《实用医药杂志》2015年第12期1082-1084,1088,共4页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨^(18)F-FDG PET-CT全身显像在不明原因肝转移癌中查找原发病灶的临床价值。方法对113例(男61例,女52例)临床或病理确诊为肝转移瘤,且已行常规影像学检查(如超声、CT、MRI等)但尚未发现原发病灶的患者,行^(18)F-FDG PET-CT全身扫描进行图像分析,并测量病灶标准摄取值(SUV)。所有PET-CT诊断原发病灶均通过病理或半年以上临床随访证实。结果 PET-CT诊断不明原因肝转移癌原发灶的真阳性率为78.76%,假阳性率为7.08%,真阴性率为5.31%,假阴性率为8.85%,诊断准确率为84.07%;真阳性组中原发灶部位主要为胃肠道及双肺,但不同原发部位肿瘤的标准摄取值(SUV)并无统计学差异。结论 ^(18)F-FDG PET-CT全身显像对查找不明原因肝转移癌患者原发病灶具有重要的临床诊断价值。Objective To investigated the clinical value of ^18F-FDG PET-CT whole body imaging in searching for primary lesions of hepatic metastatic carcinoma. Methods The 113 patients（male 61 cases,female52 cases） with liver metastasis,had received conventional imaging examination（such as ultrasonic,CT,MRI etc）.But the primary lesions were not correctly located. Then the ^18F-FDG PET-CT whole body scan was conducted and estimated the standardized uptake value（SUV） of the suspicious primary lesion. All PET-CT diagnosis of primary lesions were compared with pathology or clinical follow-up of more than half a year. Results The true positive rate of PET-CT diagnosis of hepatic metastatic carcinoma with unknown primirary site was 78.76%,false positive rate was 7.08%,true negative rate was 5.31%,false negative rate was 8.85%,the diagnostic accuracy was 84.07%. The primary tumor sites of true positive group mainly located in gastrointestinal organs and lung,but the standardized uptake values（SUV） of different primary lesions were not statistically significant. Conclusion For hepatic metastatic carcinoma unknown primary site ^18F-FDG PET-CT has incportant clinical diagnosis value.

关 键 词：肝转移癌 原发灶 正电子断层显像与CT扫描融合图像 

分 类 号：R445.3[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]