细胞粘附分子在变应性鼻炎鼻甲粘膜中的表达及其意义  

The expression of intercellular adhesion molecules in inferior turbinate mucosa of allergic rhinitis and its significance

作　　者：宋协一[1] 萧璧君[1] 倪灿荣[2] 赵舒薇[1] 林顺涨 

机构地区：[1]第二军医大学附属长征医院耳鼻咽喉科,上海200003 [2]第二军医大学附属长海医院病理科

出　　处：《临床耳鼻咽喉科杂志》2002年第8期387-389,I004,共4页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :探讨变应性鼻炎鼻甲粘膜组织中细胞粘附分子的表达及其意义。方法 :对 2 0例慢性肥厚性鼻炎、2 4例变应性鼻炎非发作期和 2 0例变应性鼻炎发作期患者下鼻甲粘膜组织石蜡切片 ,用细胞间粘附分子 1(intercellularadhesionmolecule 1,ICAM 1)和淋巴细胞功能相关抗原 1(lymphocytefunction associatedantigen 1,LFA 1)单抗进行免疫组织化学染色 ,光镜观察。结果 :与变应性鼻炎非发作期和慢性肥厚性鼻炎相比 ,变应性鼻炎发作期鼻甲组织ICAM 1和LFA 1的表达增高 (P <0 .0 1)。结论 :变应性鼻炎发作期鼻甲粘膜组织中ICAM 1和LFA 1呈高表达 ,其参与了变应性鼻炎的炎症过程。细胞间粘附分子 (ICAM 1 LFA 1)是变应性鼻炎发生、发展的重要因素之一。Objective:To study the expression of intercellular adhesion molecules in turbinate mucosa of allergic rhinitis and its significance. Method:Samples of turbinate mucosa were from 20 cases of chronic hypertrophic rhinitis, 24 cases of non provocation period allergic rhinitis and 20 cases of provocation period allergic rhinitis and their paraffin sections were studied with immunohistochemical technique staining with ICAM 1 and LFA 1 monoclone antibodies. Result:Expression of ICAM 1 and LFA 1 were higher in turbinate mucosa of provocation period allergic rhinitis than in chronic hypertrophic rhinitis and non provocation period allergic rhinitis turbinate mucosa(P< 0.01 ).Conclusion:High expression of ICAM 1 and LFA 1 in turbinate mucosa of allergic rhinitis shows that the interaction of ICAM 1/LFA 1 may participate in the inflammatory reaction of allergic rhinitis and may play an important role in the pathogenesis and development of allergic rhinitis.

关 键 词：变应性鼻炎 细胞间粘附分子-1 淋巴细胞功能相关抗原-1 鼻甲粘膜 LFA-1 ICAM-1 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]