碘-131在小鼠组织和器官的分布情况分析  

The Distribution of ^(131)I on Various Organs and Tissues in Mice

作　　者：郑贺[1] 王燕[1] 万书丽 东野广智[2] 孟庆勇[1] 

机构地区：[1]广东医学院检验医学研究所,广东东莞523808 [2]广东医学院分析中心

出　　处：《中国辐射卫生》2015年第2期101-103,共3页Chinese Journal of Radiological Health

基　　金：国家自然科学基金(81072238)

摘　　要：目的分析不同剂量碘-131在小鼠不同组织和器官的分布情况。方法给予小鼠不同剂量碘-131腹腔注射,利用γ计数器检测小鼠不同组织和器官的计数率,计算每克组织和器官摄取注射剂量百分率(%ID/g)。结果给予小鼠105Bq/g碘-131腹腔注射,24 h发现甲状腺碘-131含量明显高于心、肝、脾、肺和全血等其它组织和器官;除全血外,1 Bq/g+105 Bq/g、10 Bq/g+105Bq/g和100 Bq/g+105Bq/g三组小鼠甲状腺、心、肝、脾、胸腺等器官碘-131含量高于单纯给予105Bq/g碘-131的小鼠含量,各组间差异具有统计学意义(U<0.01,P<0.05);1 Bq/g+105Bq/g和10 Bq/g+105Bq/g组小鼠的全血碘-131含量低于单纯给予碘-131组,各组间差异具有统计学意义(U<0.05)。结论甲状腺具有明显聚碘功能,低剂量与较高剂量碘-131在心、肝、脾、胸腺等器官中表现为协同作用,在全血组织中出现适应性反应。Objective To research the distribution of131 I on various organs and tissues in mice.Methods To give the different doses of131 I in mice by intraperitoneal injection,Count by γ counter detection rate of different mouse tissues and organs,the percent of the injected does per gram（% ID / g） was calculated for each sample.Results Mice were given intraperitoneal injection of131 I with 10^5 Bq / g.The content of131 I in thyroid was higher than that of the heart,liver,spleen,lung and other tissues 24 h after the injection of131 I.Except of blood,1 Bq / g ＋ 10^5 Bq / g、10 Bq / g ＋ 10^5 Bq / g and 100 Bq / g ＋ 10^5 Bq / g the content of131 I in three groups of mice heart,liver,spleen,thymus and thyroid and other organs was significantly higher than that of pure mice of the group of 10^5 Bq / g.The two groups of 1 Bq / g ＋ 10^5 Bq / g and 10 Bq / g ＋ 10^5 Bq / g the content of131 I into blood in mice were significantly lower than those of the group of 10^5 Bq / g.Conclusion Thyroid is a clear poly iodine,performance of the highest content131 I into mice 24 hours later.Except of blood,pre131 I with 1 Bq / g,10 Bq / g and 100 Bq / g and intraperitoneal injection of 105 Bq / g of131 I in the heart,liver,spleen,thymus and thyroid and other organs showed a synergistic effect.Distribution of 1 Bq / g and 10 Bq / g receiving intraperitoneal injections of131 I can reduce the content of131 I with group of 105 Bq / g in blood,which shows an adaptive response.

关 键 词：碘-131 小鼠 体内分布 

分 类 号：R817[医药卫生—影像医学与核医学]