维持性血液透析患者抵抗素、高敏肌钙蛋白T水平变化及其与左心功能参数的相关性  

Changes of Resistin and High-sensitivity Cardiac Troponin T and Their Correlation with Left Heart Parameters in Maintenance Hemodialysis Patients

作　　者：赵万涛 王东红[2] 郭亮[3] 李洪娟[1] 王海宁[3] 张焕荣[2] 

机构地区：[1]天津市第五中心医院检验科,天津市300450 [2]天津市第五中心医院肾内科,天津市300450 [3]天津市第五中心医院超声科,天津市300450

出　　处：《中国动脉硬化杂志》2015年第8期821-824,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨维持性血液透析(MHD)患者血抵抗素、高敏肌钙蛋白T(hs-c Tn T)的变化,并分析其与左心功能参数的相关性。方法 MHD组患者60例,慢性肾衰竭非透析(non-HD)组患者45例,正常对照组40例。检测各组抵抗素、hs-c Tn T及C反应蛋白(CRP),彩色超声心动图测定左心功能参数,并行相关性分析。结果 MHD组、non-HD组抵抗素、hs-c Tn T及CRP明显高于正常对照组(均P<0.01)。MHD组左心室舒张末期内径(LVEDD)、左心室质量指数(LVMI)和左心房内径明显大于正常对照组(均P<0.01),左心室射血分数(LVEF)、左心室短轴缩短分数(LVFS)以及E/A明显小于正常对照组(均P<0.01)。non-HD组LVEDD、LVMI、左心房内径明显大于正常对照组(均P<0.01),LVEF(P<0.05)、LVFS(P<0.05)、E/A(P<0.01)明显小于正常对照组。MHD组抵抗素、hs-c Tn T、CRP、LVEDD及LVMI明显大于non-HD组(均P<0.01)。MHD组抵抗素与hs-c Tn T、CRP呈正相关(均P<0.05),抵抗素、hs-c Tn T均与LVEDD、LVMI呈正相关(均P<0.05),与LVEF、LVFS呈负相关(均P<0.05)。结论 MHD患者及non-HD患者抵抗素、hs-c Tn T、CRP明显升高。MHD患者hs-c Tn T与左心功能参数有关,抵抗素升高与MHD患者微炎症状态以及心血管疾病有关。Aim To explore changes of serum resistin,serum high-sensitivity cardiac troponin T（ hs-c Tn T） and their correlation with left heart parameters in maintenance hemodialysis（ MHD） patients. Methods 60 MHD patients,45 chronic renal failure paitients with non-hemodialysis（ non-HD） and 40 healthy controls were selected. Resistin,hs-c Tn T and C-reactive protein（ CRP） were determined. Left heart function parameters were measured. Results Resistin,hs-c Tn T and CRP were significantly higher in MHD patients and non-HD patients compared to healthy controls（ all P〈0. 01）. Left ventricular end-diastolic dimension（ LVEDD）,left ventricular mass index（ LVMI） and left atrial diameter（ LAD） were significantly higher in MHD patients compared to healthy controls（ all P〈0. 01）. Left ventricular ejection fraction（ LVEF）,left ventricular fractional shortening（ LVFS） and E / A were significantly lower in MHD patients compared to healthy controls（ all P〈0. 01）. LVEDD,LVMI and LAD were significantly higher in non-HD patients compared to healthy controls（ all P〈0. 01）. LVEF（ P〈0. 05）,LVFS（ P〈0. 05） and E / A（ P〈0. 01） were significantly lower in non-HD patients compared to healthy controls. Resistin,hs-c Tn T,CRP,LVEDD and LVMI were significantly higher in MHD patients compared to non-HD patients（ all P〈0. 01）. Resistin was positively related with hs-c Tn T,CRP（ all P〈0. 05） in MHD patients. Resistin,hs-c Tn T were positively related with LVEDD,LVMI（ all P〈0. 05）,and negatively related with LVEF,LVFS（ all P〈0. 05） in MHD patients. Conclusions Resistin,hs-c Tn T and CRP were increasing significantly in MHD patients and non-HD patients. There were correlation of hs-c Tn T with left heart function parameters in MHD patients. The higher level of resistin in MHD patients may relate to their microinflammatory status and cardiovascular diseases.

关 键 词：维持性血液透析 抵抗素 高敏肌钙蛋白T 心血管疾病 

分 类 号：R692[医药卫生—泌尿科学]