阿托伐他汀对急性脑梗死患者血清心肌型脂肪酸结合蛋白和氧化型低密度脂蛋白水平的影响  

Atorvastatin Influence on Serum Level of Heart Fatty Acid Binding Protein and Oxidized Low Density Lipoprotein in the Patients of Acute Cerebral Infarction

作　　者：何永利 黄廷富 潘小平 

机构地区：[1]重庆市职业病防治院内二科,重庆市400060 [2]重庆市职业病防治院内三科,重庆市400060 [3]重庆市职业病防治院放射科,重庆市400060

出　　处：《中国动脉硬化杂志》2015年第8期834-836,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的观察阿托伐他汀对急性脑梗死患者心肌型脂肪酸结合蛋白(H-FABP)和氧化型低密度脂蛋白(ox-LDL)血清水平的影响,探讨阿托伐他汀对急性脑梗死的脑保护作用机制。方法实验分为4组:急性脑梗死血脂正常组、急性脑梗死高血脂组、急性脑梗死血脂正常治疗组、急性脑梗死高血脂治疗组。双抗体夹心ELISA法测定H-FABP和ox-LDL水平,生物化学法测定血脂水平。结果急性脑梗死高血脂患者及急性脑梗死血脂正常者经过阿托伐他汀治疗后H-FABP浓度明显降低(P<0.05),ox-LDL浓度明显降低(P<0.01)。结论阿托伐他汀能够降低急性脑梗死血清H-FABP和ox-LDL浓度,明显缓解急性脑梗死神经功能缺损症状,推测阿托伐他汀对急性脑梗死脑保护作用可能通过抑制脑缺血后脑组织的进一步损伤、抑制氧化应激效应这一途径实现的。Aim To observe the influence of atorvastatin on serum level of heart fatty acid binding protein（ HFABP）,oxidized low-density lipoprotein（ ox-LDL） in the patients of acute cerebral infarction. Methods Patients were divided into 4 groups： normal blood lipid level group with acute cerebral infarction（ CI）,higher blood lipid level group with acute cerebral infarction（ CIH）,atorvastatin treatment for acute cerebral infarction（ CIT）,atorvastatin treatment for higher blood lipid with acute cerebral infarction（ CIHT）. H-FABP and ox-LDL were measured by enzyme linked immunosorbent assay,blood lipid level was measured by biochemistry. Results The serum level of H-FABP was lower in CIHT,CIT groups than that of CIH,CI groups（ P〈0. 05）. The serum level of ox-LDL in CIHT,CIT groups was lower than that of CI and CIH groups（ P〈0. 01）. Conclusions Atorvastatin can decrease the serum level of HFABP and ox-LDL,and attenuate neurological deficit in the patients of acute cerebral infarction. The hypothesis of atorvastatin neuroprotection was made that atorvastatin may extenuate brain tissue damage and retard oxidation from acute cerebral infarction.

关 键 词：阿托伐他汀 急性脑梗死 心肌型脂肪酸结合蛋白 氧化型低密度脂蛋白 

分 类 号：R5[医药卫生—内科学]