日本血吸虫病肝纤维化的病理学及发病机制研究进展  

Pathology and pathogenesis of liver fibrosis induced by Schistosoma japonicum

作　　者：宋兰桂 吴忠道[1] 

机构地区：[1]中山大学中山医学院寄生虫学教研室、教育部热带病防治重点实验室,广州510080

出　　处：《中国血吸虫病防治杂志》2015年第2期213-216,220,共5页Chinese Journal of Schistosomiasis Control

摘　　要：血吸虫病是一种流行广泛、严重危害人类健康和社会经济发展的人兽共患寄生虫病。我国是日本血吸虫病流行最严重的国家之一。宿主感染血吸虫后虫卵沉积于肝脏,引起机体免疫应答,导致以淋巴细胞、嗜酸性粒细胞和巨噬细胞浸润为主要特征的肝脏虫卵肉芽肿病变,该慢性炎症过程最终会引起肝纤维化并出现腹水、肝脾肿大等临床表现。本文将从血吸虫病肝纤维化病理学特征、肝纤维化的形成与调节、重要的炎症因子及信号通路、nc RNA在血吸虫病肝纤维中的调控作用以及抗纤维化治疗和新药研究等几个方面进行综述。Schistosomiasis is a widely distributed parasitic zoonoses that threatens human＇ s health and social economic development. China is one of the most endemic countries in the world. Schistosoma egg are mainly lodged in the liver and intestinal tissues. There, the eggs induce a granulomatous host immune response largely characterized by lymphocytes, eosinophils, and alternatively activated macrophages. The process of granuloma formation induces chronic inflammation that leads to liver fibrosis accompanied by obvious manifestations such as hepatosplenomegaly and ascites. In this article, we review the advanced progress in research about schistosomiasis hepatic fibrosis, including the pathology of liver fibrosis, the formation and modulation of granuloma and fibrosis, the key inflammatory factors and related signaling pathways, the regulatory role of ncRNA in the process of fibrosis, and anti-fibrosis treatment and new drugs development.

关 键 词：血吸虫病 肝纤维化 病理学 发病机制 

分 类 号：R532.1[医药卫生—内科学]