三七总皂苷对脑缺血/再灌注损伤保护机制的研究进展  

Research Progress in Protective Mechanism of Panax Notoginsenosidum on Cerebral Ischemia-Reperfusion Injury

作　　者：翟晓晨[1] 吴捷[1] 

机构地区：[1]西安交通大学医学部基础医学院药理学系,西安710061

出　　处：《中国药学杂志》2016年第1期6-9,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81273501;81470378)

摘　　要：三七总皂苷(panax notoginsenosidum,PNS)具有增加脑血流量,改善微循环和抗血小板聚集等作用,在临床上广泛用于脑缺血/再灌注损伤(cerebral ischemia-reperfusion injury,CIRI)的治疗。目前研究认为,三七总皂苷对脑缺血/再灌注损伤的保护机制涉及其对自由基及脂质过氧化物、细胞凋亡、钙通道、神经元损伤、相关信号通路蛋白表达等多方面作用。这些结果为三七总皂苷的合理开发和应用提供了充分的科学依据。笔者对近年来国内外有关文献进行了检索和分析,现对三七总皂苷保护脑缺血/再灌注损伤机制的研究进展予以综述。Panax notoginsenosidum（PNS） , which was proved to have the efficacy of increasing cerebral blood flow, improving micro- circulation and anti-platelet aggregation, has been widely used for the treatment of cerebral isehemia-reperfusion injury（CIRI）. A line of current studies have shown that the protective mechanism of PNS on CIRI is associated with multiple ways, including the roles of PNS on free radicals and lipid peroxides, apoptosis, calcium channels, neuronal damage, and the protein expression of signaling path- ways etc. The above protective mechanisms underlying the role of PNS on CIRI provide well-founded scientific evidences for the exploi- tation and application of PNS. In this paper, the progress in protective mechanism of PNS on CIRI by summarizing and analyzing data collected from literatures published in recent years is reviewed.

关 键 词：三七总皂苷 脑缺血/再灌注损伤 保护机制 

分 类 号：R965[医药卫生—药理学]