系统性红斑狼疮证型及用药规律现代文献研究  

Modern Literature Research on The Syndrome and Mecication Rule of Systemic Lupus Erythematosus

作　　者：朱震[1] 张世勤[1] 高治国[2] 汪悦[3] 

机构地区：[1]南京中医药大学第二临床医学院,江苏省南京市210023 [2]南京中医药大学信息技术学院 [3]南京中医药大学第一临床医学院

出　　处：《中医杂志》2016年第1期71-74,共4页Journal of Traditional Chinese Medicine

基　　金：江苏省2012年度普通高校研究生科研创新计划

摘　　要：目的基于现代文献探讨系统性红斑狼疮的证候分布及用药规律。方法检索中国知识资源总库、维普中文科技期刊数据库、万方数据库中医药治疗系统性红斑狼疮的相关文献,时间限定为从数据库创立至2014年9月。提取纳入文献证候及用药信息,进行统一规范化处理后建立系统性红斑狼疮中医治疗数据库,对其证型、药物及其类别进行频数分析,统计支持度、置信度等项目,对高频药对进行关联规则分析。结果最终纳入文献106篇,提取证型49个,涉及中药291味。证型出现频次最高的前5位依次为热毒炽盛(40)、阴虚内热(30)、脾肾阳虚(25)、肝肾阴虚(21)、气阴两虚(21);单味药出现频次最高的前5位依次为生地黄(131)、牡丹皮(110)、甘草(84)、黄芪(83)、茯苓(81);出现频次>10次的69味药物类别出现频次前5位的依次为补虚药(814)、清热药(862)、活血化瘀药(172)、利水渗湿药(179)、祛风湿药(61);药物中关联度较好的药对共15对,支持度最高的前5位依次为牡丹皮—生地黄,赤芍—生地黄,赤芍—牡丹皮,生地黄—玄参,生地黄—知母。结论系统性红斑狼疮病理性质总属本虚标实,虚常表现为阴虚、气虚,热邪、瘀血是主要致病因素,故临证补虚为必要治疗手段,而凉血散瘀法是临床常用治疗大法。Objective To explore the syndrome distribution and herb use rule of systemic lupus erythematosus based on modern Literatures study. Methods Retrieve related literatures from the China Knowledge Resources Integral Databases, Vip Database of Chinese Scientific and Technical Periodicals and Wanfang database on traditional Chinese medicine treatment of systemic lupus erythematosus. Literatures from the begining of the database to September 2014 were collected. Extract the information on syndrome and herb use from the included literatures. After standard- ized processing of the information, the traditional Chinese medicine treatment database for systemic lupus erythemato- sus would be established, frequency of the syndromes, herbs and their categories would be analysed, degree of sup- port, confidence and other items would be calculated, association rules for high frequency medicine would be ana- lysed. Results Totally 106 literatures were included, 49 syndrome types were extracted, 291 Chinese medicine were involved. The top five frequency of syndromes appeared are followed by toxic heat flourishing （40）, internal heat due to yin deficiency （30）, Yang deficiency of spleen and kidney （25）, Yin deficiency of liver and kidney （21）, deficiency of both Qi and Yin （21） ; The highest frequency of single herb medicine appeared in the top five are followed by Sheng Dihuang （Radix Rehmanniae recens, 131 ）, Mudan Pi （Cortex radicis Paeoniae suffruticosae, 110）, Gancao （Radix Glycyrrhizae, 84）, Huangqi （ Radix Astragali, 83 ）, and Fuling （ Sclerotium Poriae, 81 ）. The top five types of the 69 kinds of herbs with occurrence frequency more than 10 times are followed by tonic medi- cine （814）, heat clearing herbs （862）, promoting blood circulation and removing blood stasis medicine （172）, diuretics for eliminating dampness （ 179）, rheumatism medicine （61）. There are 15 pairs of herbs with closer degree of relation, the highest degree of support of the top five are followed

关 键 词：系统性红斑狼疮 证候 用药规律 文献研究 

分 类 号：R259[医药卫生—中西医结合]