乳腺癌超声图像特征与ER、PR、CerbB-2的相关性研究  

Correlation of ultrasonographic characteristics with expression of ER,PR and CerbB-2 in breast cancer

作　　者：徐乐[1] 何琳[1] 陈涛[2] 邱敏[1] 

机构地区：[1]重庆医科大学附属大学城医院超声科,重庆401331 [2]重庆医科大学附属第一医院病理科,重庆400016

出　　处：《第三军医大学学报》2016年第2期182-186,共5页Journal of Third Military Medical University

摘　　要：目的探讨乳腺癌超声声像图特征与其分子生物学指标雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)及原癌基因(Cerb B-2)之间的关系。方法回顾性分析2013年10月至2014年11月重庆医科大学附属第一医院内分泌乳腺外科94例经病理证实为乳腺癌患者[女性,年龄(51.5±10.6)岁]的超声声像图表现及石蜡切片,分析超声声像图特征与ER、PR、Cerb B-2之间的关系。结果肿瘤的形态、大小及纵横比与ER、PR及Cerb B-2无相关性(P>0.05);在边缘有高回声晕者及肿瘤后方回声衰减者中ER的阳性表达率差异有统计学意义(P<0.05);边缘有毛刺征组中,ER、PR阳性表达率均高于无此征象者(P<0.05);微钙化的出现及丰富的血流与Cerb B-2的阳性表达相关(P<0.05);淋巴结转移与ER、PR阴性表达及Cerb B-2的阳性表达有关(P<0.05)。结论乳腺癌超声声像图特征与分子生物学指标之间存在一定的相关性,有毛刺征、高回声晕及无淋巴结转移的乳腺癌有更高的ER阳性表达率,更适合内分泌治疗,患者预后较好;有微钙化、血流较丰富及淋巴结转移的乳腺癌Cerb B-2的阳性表达率较高,预示肿块的恶性度高,预后不良。Objective To investigate the correlation of ultrasonographic characteristics with molecular markers including estrogen receptor（ ER）,progesterone receptor（ PR）,and human epidermal growth factor receptor 2（ Cerb B-2） in breast cancer,and provide the basis for judging biological behaviors of breast lesions and prognosis of patients. Methods The ultrasonographic characteristics and paraffin sections of 94 cases of breast cancer from the endocrine breast surgery department of the first affiliated hospital of Chongqing medical university were analyzed retrospectively in this study. All the patients were female,with an average age of 51.5 ± 10. 6 years old,and all the cases were confirmed by histopathology. The correlation of ultrasonographic characteristics with the ER,PR and Cerb B-2 expression was analyzed. Results There was no correlation between the shape,size and orientation of tumor and the expression of ER,PR and Cerb B-2（ P〈0. 05）.Tumors with hyperechoic halo sign and posterior shadow were correlated with the positive expression of ER,and the differences were statistically significant（ P〈0. 05）. The positive expression of ER and PR in the tumors with edge spiculated sign were significantly higher than those in the tumors without the sign（ P〈0. 05）. The microcalcification and plentiful blood flow were related with the positive expression of Cerb B-2（ P〈0. 05）. Axillary lymph node metastasis was correlated with the negative expression of ER and PR and the positive expression of Cerb B-2（ P〈0. 05）. Conclusion There is certain correlation between ultrasonographic characteristics and molecular markers in breast cancer. The breast tumors with spiculation and hyperechoic halo and without axillary lymph node metastasis are correlated with positive expression of ER,more suitable for endocrine therapy,and have good prognosis. The breast tumors with microcalcification,plentiful blood flow and axillary lymph node metastasis have high expression of Cerb B-2,indicating malignant tu

关 键 词：乳腺癌 超声诊断 雌激素受体 孕激素受体 原癌基因 

分 类 号：R445.1[医药卫生—影像医学与核医学]