Mohnarin脑脊液分离菌耐药性的动态分析  

Dynamic Analysis of Drug Resistance of Mohnarin Cerebrospinal Fluid Isolates

作　　者：陈丽霞[1] 明德松[1,2] 龚国梅 邱伟智[4] 黄东红[5] 王翠娥[4] 林美 

机构地区：[1]泉州医学高等专科学校基础医学部,福建泉州362011 [2]福建医科大学附属泉州第一医院检验科,福建泉州362000 [3]泉州医学高等专科学校护理系,福建泉州362011 [4]福建医科大学附属第二医院神经外科,福建泉州362000 [5]福建医科大学附属第二医院检验科,福建泉州362000

出　　处：《中国药房》2016年第2期184-188,共5页China Pharmacy

基　　金：国家骨干院校建设重点资助项目(No.XJ1306;2014XJ1313);2014年度泉州市社会发展领域科技计划项目(No.2014Z24);2015年度泉州市社会发展领域科研与示范应用项目(No.2015Z93)

摘　　要：目的:为临床控制感染与经验治疗提供参考。方法:收集2006-2011年Mohnarin脑脊液分离菌报告文献资料,用SPSS.19.0软件进行统计。结果:我国2006-2011年临床脑脊液分离菌中革兰阳性(G^+)菌呈上升趋势,革兰阴性(G^-菌)呈下降趋势,且差异有统计学意义(χ~2=12.952,P=0.01)。葡萄球菌耐药率总体出现明显逐年下降的趋势,差异有统计学意义(P<0.001),尤其是红霉素,对左氧氟沙星和环丙沙星的耐药率略有下降,但差异无统计学意义(P>0.05);未发现金黄色葡萄球菌耐万古霉素、利奈唑胺菌株。肠球菌对万古霉素的耐药率明显上升,差异有统计学意义(P<0.001),对左氧氟沙星耐药率差异无统计学意义(P>0.05),未发现耐利奈唑胺菌株。G-菌对常用抗菌药物的耐药性均呈逐年上升趋势,以不动杆菌属多重耐药的情况较为严重,其对常用抗菌药物的耐药性明显逐年升高,差异有统计学意义(P<0.001)。结论:我国脑脊液的临床分离菌中表皮葡萄球菌和不动杆菌属逐年增多,脑脊液的临床分离菌G^+菌耐药性大部分呈下降趋势,G^-菌均呈现明显增加趋势。OBJECTIVE：To provide reference for clinical infection control and experiential therapy.METHODS：From 2006 to 2011,Mohnarin cerebrospinal fluid（CSF） isolates reports and literatures were collected and analyzed statistically by using SPSS.19.0 software.RESULTS：During 2006-2011,Gram-positive bacteria in CSF isolates were on the rise,and Gram-negative bacteria were decreased,with statistical significance（χ^2=12.952,P=0.01）.Resistance rate of Staphylococcus showed a significant decrease trend,with statistical significance（P〈0.001）,especially to Erythromycin.Resistance rate of Staphylococcus to levofloxacin and ciprofloxacin had declined slightly,but there was no statistical significance（P〉0.05）.That Staphylococcus aureus resistant to vancomycin and linezolid had not been found.Resistance rate of Enterococcus to vancomycin increased significantly,with statistical significance（P〈0.001）;to levofloxacin,there was no statistical significance（P〉0.05）;linezolid-resistant strains was not found.Resistance rate of Gram-negative bacterial to antibiotics increased gradually year by year,especially multiple drug resistance of Acinetobacter;that of Acinetobacter to commonly used antibiotics increased significantly,with statistical significance（P〈0.001）.CONCLUSIONS：Among CSF clinical isolates,Staphylococcus epidermis and Acinetobacter are increasing year by year;drug resistance of Gram-positive bacteria show a downward trend,while Gram-negative bacteria tend to increase significantly.

关 键 词：全国细菌耐药性监测网脑脊液 微生物 抗菌药物 耐药性 动态分析 

分 类 号：R969.3[医药卫生—药理学]