我院鲍曼不动杆菌耐药性与抗菌药物使用强度相关性分析  

Association between Antibiotic Use Density and Acinetobacter baumannii Drug Resistance in Our Hospital

作　　者：叶丹[1] 李常安[1] 梁素媚 陈文瑛[2] 肖翔林[2] 黎毅敏[3] 毛璞[1] 

机构地区：[1]广州医科大学附属第一医院医院感染管理科,广州510120 [2]广州医科大学附属第一医院药学部,广州510120 [3]呼吸疾病国家重点实验室/广州呼吸疾病研究所,广州510120

出　　处：《中国药房》2016年第2期189-191,共3页China Pharmacy

基　　金：广东省医学科学技术研究基金(No.A2014295)

摘　　要：目的:为临床合理用药提供参考。方法:采用回顾性调查方法,对我院2010-2014年住院患者常用抗菌药物的使用强度及鲍曼不动杆菌对其的敏感率进行统计,应用Pearson和Spearman相关法进行相关性分析。结果:2010-2014年,我院住院患者临床微生物标本检出鲍曼不动杆菌共2 537株。鲍曼不动杆菌对美洛培南和亚胺培南的敏感率与其对应的药物使用强度呈显著负相关(相关系数分别为0.990、0.930,P<0.05);对复方新诺明、环丙沙星、米诺环素、哌拉西林钠他唑巴坦钠、头孢吡肟、头孢哌酮钠舒巴坦钠、头孢他啶和左旋氧氟沙星的敏感率与其药物使用强度无关。结论:碳青霉烯类抗菌药物的使用是导致鲍曼不动杆菌耐药的重要因素之一。OBJECTIVE：To provide reference for rational drug use in the clinic.METHODS：By retrospective investigation,antibiotic use density（AUD）and sensitivity rates of Acinetobacter baumannii to commonly used antibiotics in the inpatients were analyzed statistically in our hospital during 2010-2014,and the relationship between AUD and drug resistance of A.baumannii were analyzed with Pearson and Spearman method.RESULTS：2 537 strains of A.baumannii were detected in clinical microbiological specimen of inpatients from our hospital during 2010-2014.The sensitivity rates of A.baumannii to meropenem and imipenem were negatively correlated to AUD（r=0.990,0.930,P〈0.05）.The sensitivity rate of A.baumannii to trimethoprim-sulfamethoxazole,ciprofloxacin,minocycline,piperacillin-tazobactam,cefepime,cefoperazone-sulbactam,ceftazidime and levofloxacin were not correlated to AUD.CONCLUSIONS：The use of carbopenems is an important factor to drug resistance of A.baumannii.

关 键 词：鲍曼不动杆菌 抗菌药物 耐药性 使用强度 相关性 

分 类 号：R978.1[医药卫生—药品]