注射用奥扎格雷钠与含果糖注射液的配伍稳定性考察  

Study on the Compatibility Stability of Ozagrel Sodium for Injection and Injection Containing Fructose

作　　者：王成湖 易林高[2] 

机构地区：[1]瑞安市妇幼保健院,浙江瑞安325200 [2]瑞安市人民医院,浙江瑞安325200

出　　处：《中国药房》2016年第2期191-192,共2页China Pharmacy

摘　　要：目的：考察注射用奥扎格雷钠与3种含果糖注射液的配伍稳定性。方法：将注射用奥扎格雷钠分别与5%果糖注射液、5%果糖氯化钠注射液及5%转化糖注射液配伍后,置25℃恒温水浴箱中,于0、1、2、4、6 h时观察配伍液外观变化,测定配伍液p H值,并采用高效液相色谱（HPLC）法测定配伍液中奥扎格雷钠的含量。结果：注射用奥扎格雷钠与上述3种注射液配伍6 h内外观无明显变化,p H值变化范围在0.002~0.156之间,含量由100%下降至95.7%。结论：注射用奥扎格雷钠与5%果糖注射液、5%果糖氯化钠注射液和5%转化糖注射液分别配伍后随时间的变化,奥扎格雷钠含量呈减少的趋势,建议在实际应用中应在配伍后6 h内滴注完毕。OBJECTIVE：To investigate the compatibility stability of ozagrel sodium for injection with 3 kinds of injection containing fructose.METHODS：Ozagrel sodium for injection was mixed with 5% fructose injection,5% fructose and sodium chloride injection and 5% calorose injection respectively,and then placed in constant temperature water bath at 25 ℃;0,1,2,4,6 h later,the appearance and p H of mixture were observed and determined,and HPLC method was adopted to determine the content of ozagrel sodium in mixture.RESULTS：There was no significant changes in appearance,and p H ranged from 0.002 to 0.156,the content decreased from 100% to 95.7%within 6 hours after ozagrel sodium for injection mixed with 3 kinds of injection.CONCLUSIONS：After ozagrel sodium for injection mixed with 5% fructose injection,5% fructose and sodium chloride injection and 5% calorose injection,the content of ozagrel sodium decrease gradually as times.In the practice,the mixture should be used up within 6 h.

关 键 词：奥扎格雷钠 配伍 稳定性 高效液相色谱法 含量 

分 类 号：R969.2[医药卫生—药理学]