宫颈癌患者腹腔镜术后应用动脉介入化疗的临床观察  

Clinical Observation of Arterial Interventional Chemotherapy for Cervical Cancer Patients after Laparoscope Surgery

作　　者：董耘[1] 李斌[1] 柯丽娜[1] 国宏莉[2] 

机构地区：[1]湖北医药学院附属东风医院妇产科,湖北十堰442000 [2]湖北医药学院,湖北十堰442000

出　　处：《中国药房》2016年第2期222-224,共3页China Pharmacy

基　　金：湖北省教育厅科研项目(No.B2013122)

摘　　要：目的:观察宫颈癌患者腹腔镜术后应用动脉介入化疗的疗效及毒副反应。方法:160例宫颈癌患者,按随机数字表法分为治疗组和对照组,各80例。两组患者均行腹腔镜辅助阴式子宫广泛切除术,术后对照组患者采用紫杉醇+卡铂(TC方案)传统静脉化疗;治疗组患者采用TC方案动脉介入化疗。观察两组患者治疗后有效率、生存时间、生存率及毒副反应。结果:治疗后,治疗组患者有效率(90.0%)显著高于对照组(75.0%),差异均有统计学意义(P<0.05);治疗组与对照组患者平均生存时间分别为(23.45±5.33)、(19.29±6.13)月,生存率分别为91.3%、78.8%,差异有统计学意义(P<0.05);两组患者在治疗期间均出现不同程度的骨髓抑制及恶心呕吐等胃肠道反应,治疗组患者毒副反应发生的例数与严重程度均明显低于对照组,差异有统计学意义(P<0.05)。结论:动脉介入化疗能提高宫颈癌患者腹腔镜术后化疗效果,且毒副反应少,患者生存率提高。OBJECTIVE：To observe therapeutic efficacy and toxic reaction of arterial interventional chemotherapy for cervical cancer patients after laparoscope surgery.METHODS：160 patients with cervical cancer were randomly divided into treatment group and control group,with 80 cases in each group.Both groups received laparoscope assistied vagina hysterectomy.After surgery,control group was given traditional intravenous chemotherapy of paclitaxel＋carboplatin（TC scheme）;treatment group was given TC scheme arterial interventional chemotherapy.Effective rate,survival time,survival rate and toxic reaction were observed in 2 groups after treatment.RESULTS：After treatment,effective rate of treatment group（90.0%）was significantly higher than that of control group（75.0%）,with statistical significance（P〈0.05）.Mean survival time of treatment group and control group was（23.45±5.33）month and（19.29±6.13）month,and survival rates of 2 groups were 91.3% and 78.8%,with statistical significance（P〈0.05）.Both groups suffered from gastrointestinal reactions as myelosuppression,nausea,vomiting at different degree;the case number and severity of toxic reaction in treatment group were significantly lower than control group,with statistical significance（P〈0.05）.CONCLUSIONS：Arterial interventional chemotherapy can improve chemotherapy effect of malignant cervical cancer with less toxic reaction,and promote survival of patients.

关 键 词：宫颈癌 腹腔镜手术 新辅助化疗 动脉介入化疗 紫杉醇 卡铂 

分 类 号：R711.32[医药卫生—妇产科学]