2008-2013年山东省神经管缺陷发生率的动态变化  

Dynamic change of incidence rate of neural tube defects in Shandong province from 2008 to 2013

作　　者：张蓬 李舸[2] 周凤荣 倪晨曦 

机构地区：[1]山东省妇幼保健院,山东济南250000 [2]约翰霍普金斯大学

出　　处：《中国妇幼保健》2016年第1期81-83,共3页Maternal and Child Health Care of China

基　　金：山东省科技发展计划项目(GG2302050)

摘　　要：目的了解2008-2013年山东省神经管缺陷(NTDs)发生率的变化趋势。方法采用以医院为基础的监测方法收集资料,调查对象为孕28周至生后7 d的围产儿,对2008-2013年全省17市出生缺陷监测网监测的673 361例围产儿,129例NTDs病例进行回顾性分析。结果 NTDs发生率由2008年2.9/万下降到2013年的1.5/万,6年下降了48.3%,年下降率10.4%,农村NTDs下降幅度为60.0%,城市为5.6%;脊柱裂、脑膨出发生率分别下降了60.0%和33.3%。结论山东省NTDs发生率呈下降趋势,农村下降幅度大于城市;脊柱裂、脑膨出发生率下降较快。神经管缺陷儿出生素质差,围产期病死率高,预后不良。加强预防和产前诊断是降低发生率的有效措施。Objective To understand the change trend of incidence rate of neural tube defects （NTDs） in Shandong province from 2008 to 2013. Methods The data was collected by hospital-based monitoring method, the respondents were perinatal infants from 28 gestational week to 7 days after birth, 673 361 perinatal infants monitored by Shandong Provincial Birth Defect Monitoring Network and 129 NTDs cases were analyzed retrospectively from 2008 to 2013. Results The incidence rate of NTDs decreased by 48.3% from 2. 9 per 10 000 in 2008 to I. 5 per 10 000 in 2013, the yearly decrease rate was 10.4% , the incidence rates of NTDs in rural area and urban area decreased by 60. 0% and 5. 6%, respectively; the incidence rates of spina hifida and encephaloeele decreased by 60. 0% and 33.3%, respectively. Conclusion The incidence rate of NTDs showed a decreasing trend in Shandong province, the decrease amplitude in rural area was larger than that in urban area; the incidence rates of spina bifida and encephalocele decreased rapidly. The birth quality of NTDs infants is poor, the case fatality rate of perinatal infants is high, and the prognosis is poor. Strengthening prevention and prenatal diagnosis are effective measures to reduce the incidence rate of NTDs.

关 键 词：神经管缺陷 流行病学 监测 动态变化 

分 类 号：R714.53[医药卫生—妇产科学]