Examination of the Stability of Amoxicillin in Compounded Suppositories and Ointments  

作　　者：Malgorzata Zdzieborska Ewa Siedlecka Izabela Orlowska 

机构地区：[1]Department of Applied Pharmacy and Bioengineering, Medical University of Warsaw, Poland

出　　处：《Journal of Pharmacy and Pharmacology》2016年第2期64-72,共9页药剂与药理学（英文版）

摘　　要：We examined the stability of amoxicillin trihydrate from the preparation Augmentin in compounded forms of drugs such as vaginal suppositories and ointments. The quantity of the antibiotic in the preparations studied was determined directly after they had been made and after a lapse of 7 and 14 days. We also carried out comparative examinations of the stability of sodium amoxicillin （Tarommentin） and sodium ampicillin （Ampicillin） in ointments with an addition of a boric acid solution. The examinations confirmed the stability of amoxicillin trihydrate in suppositories and in anhydrous and hydrated ointments. The content of this antibiotic in ointmems with an addition of a boric acid solution decreases slightly. Comparative studies of the stability of sodium amoxicillin and sodium amoxicillin revealed a markedly lower stability of the two antibiotics in comparison to the stability of amoxicillin trihydrate.

关 键 词：AMOXICILLIN AMPICILLIN vaginal suppositories OINTMENTS stability 

分 类 号：TQ611[化学工程—精细化工] TQ465.1