可生物降解的聚磷酸异山梨醇酯的合成与表征  

Synthesis and Characterization of a Biodegradable Poly( phospho-isosorbide) Ester

作　　者：王亚兵[1] 赵锦波[1] 李晓栓[1] 刘婷[1] 余定华[1,2] 

机构地区：[1]南京工业大学生物与制药工程学院 [2]材料化学国家重点实验室,南京210009

出　　处：《高分子学报》2016年第1期40-45,共6页Acta Polymerica Sinica

基　　金：国家重点基础研究发展计划(973计划;项目号2011CB710806);国家自然科学基金(基金号21376120)资助

摘　　要：由异山梨醇和苯膦酰二氯经本体聚合法和溶液聚合法得到了不同分子量的新型聚磷酸酯（PPI）,采用傅立叶变换红外（FTIR）,核磁共振氢谱（^1H-NMR）和凝胶渗透色谱（GPC）对聚酯的组成和分子量进行表征,结果表明产物为聚磷酸酯结构.聚合物在水溶液和酶溶液中的降解和溶胀实验表明,当PPI的分子量（Mw）低于5×10^4时,聚合物具有很好的降解性能和溶胀性能,25天后其降解率达到80%,溶胀率达到150%.当M_w高于5×10^4时,其降解速率和吸水率明显下降,25天后降解率和溶胀率分别仅为25%和40%.研究了PPI的玻璃化转变温度（Tg）和分子量的关系,PPI具有较高的Tg,且随着分子量的增加,聚合物的Tg显著增加.当PPI的分子量为6×10^4时,其玻璃化转变温度达到176℃.同时研究了聚合物分子量对其热稳定性的影响,当重均分子量由2×10^4增加到6×10^4时,PPI的起始分解温度从260℃提高到315℃.结果表明提高分子量有助于提高PPI的热分解温度.A novel poly（ phospho-isosorbide） ester（ PPI） with series of molecular weight was synthesized from isosorbide and phenyl phosphonic acyl chloride by bulk polymerization and solution polymerization. The structures and molecular weights of PPI were characterized by Flourier transform infrared spectroscopy（ FTIR）,nuclear magnetic resonance（^1H-NMR） and gel permeation chromatography（ GPC）. The degradation and swelling experiments of the polymer in aqueous solutions and enzyme solutions showed that it had good biodegradation properties and swelling properties when Mwwas below 5 × 10^4. The degradation rate of PPI was80%,and swelling rate of PPI was 150% after 25 days. However the degradation and swelling rate decreased obviously when Mwwas over 5 × 10^4. The degradation rate and swelling rate of PPI were only 25% and 40%,respectively. It showed that PPI had high glass transition temperature（ T_g）,which increased significantly with the increasing of its molecular weight. For example,the glass transition temperature（ Tg） reached to 176 ℃when Mw was 6 × 10^4. The influence of molecular weight on the thermal stability indicated that higher molecular weight was beneficial for improving thermal decomposition temperature of the PPI. The initial decomposition temperature（ T5%） of PPI increased from 260 ℃ to 315 ℃,while the Mw was raised from 2 × 10^4 to 6 × 10^4.

关 键 词：异山梨醇 苯膦酰二氯 聚磷酸酯 生物降解 热性能 

分 类 号：O631[理学—高分子化学]