阿托伐他汀在急性缺血性脑卒中患者中的临床研究  

Clinical effects of atorvastatin in patients with acute ischemic stroke

作　　者：周红霞[1] 王兴元[1] 范利娟[1] 杨善进[1] 曹洪兵[1] 吴占敖[1] 

机构地区：[1]中国人民解放军第三五九医院内科,江苏镇江212001

出　　处：《中国临床药理学杂志》2016年第1期72-74,共3页The Chinese Journal of Clinical Pharmacology

基　　金：全军医药卫生科研基金资助项目(ZX13)

摘　　要：目的评价阿托伐他汀在急性缺血性脑卒中患者中的疗效与安全性。方法 128例急性缺血性脑卒中患者随机分为阿托伐他汀20 mg组和阿托伐他汀10 mg组,分别口服阿托伐他汀20,10 mg,治疗6个月,观察2组患者的血脂、神经功能缺损评分,斑块面积的变化和不良反应。结果阿托伐他汀20 mg组总有效率(98.4%)明显高于阿托伐他汀10 mg组(84.4%)(P<0.05)。2组患者治疗后的血脂、神经功能缺损评分及斑块面积明显优于治疗前(P<0.05);且阿托伐他汀20 mg组明显优于阿托伐他汀10 mg组(P<0.05)。2组的不良反应发生率均为4.7%,差异无统计学意义(P>0.05)。结论阿托伐他汀20 mg能更好地改善急性缺血性脑卒中患者的症状,改善患者的血脂水平及斑块面积,提高患者的生活水平。Objective To explore the clinical effects of two doses of atorvastatin in patients with acute ischemic stroke. Methods A total of128 patients with acute ischemic stroke were randomly divided into two groups,64 cases in each group. The patients in atorvastatin 20 mg group were given atorvastatin 20 mg daily,and the patients of the atorvastatin10 mg group were given atorvastatin 10 mg daily. The treatment lasted for six months. Blood lipid,nerve function defect grading,atherosclerotic plaque area and adverse drug reactions were observed before and after six months. Results The total effective rate in the atorvastatin 20 mg group（ 98. 4%） was significantly higher than that in the atorvastatin 10 mg group（ 84. 4%）（ P〈0. 05）. Blood lipid,nerve function defect grading and atherosclerotic plaque area were obviously improved in two groups（ P〈0. 05）,and the atorvastatin 20 mg group had a better improvement against the atorvastatin 10 mg group（ P〈0. 05）. The incidence of adverse drug reactions in two groups were 4. 7%,no statistical significance（ P〉0. 05）. Conclusion Aatorvastatin 20 mg can better improve the clinical symptoms,blood lipid level as well as atherosclerotic plaque area in patients with acute ischemic stroke,accordingly improve the quality of life in those patients.

关 键 词：急性缺血性卒中 不同剂量 阿托伐他汀 临床效果 

分 类 号：R972.6[医药卫生—药品] R743[医药卫生—药学]